小剂量甘露醇用于急性中、重症脑卒中患者救治临床效果及不良反应观察  

Clinical effect and adverse reaction of low dose mannitol in treatment of acute moderate and severe cerebral apoplexy patients

作　　者：周巍 陈亮 李华亮[2] 

机构地区：[1]江苏省盐城市急救医疗中心,224000 [2]江苏省盐城市第三人民医院,224000

出　　处：《首都食品与医药》2021年第17期53-55,共3页Capital Food Medicine

基　　金：盐城市科研计划项目(项目编号:YK2018059)。

摘　　要：目的分析急性中、重症脑卒中采用小剂量甘露醇救治的临床效果,观察其不良反应发生情况和生活质量。方法回顾分析2019年1月1日-2020年12月30日期间我中心急救科救治的80例急性中、重症脑卒中患者,按甘露醇治疗剂量分为对照组和观察组,每组40例。对照组给予(大剂量)250ml20%甘露醇治疗,观察组给予(小剂量)125ml20%甘露醇治疗,观察两组的不良反应、救治效果、生活质量等。结果观察组治疗总有效率为92.50%、不良反应发生率为20.00%,对照组分别为75.00%、42.50%,差异均有统计学意义(P<0.05)。随访半年评估患者生活质量水平发现,观察组总评分为(82.16±1.27)分,对照组为(65.81±3.77)分,差异具有统计学意义(P<0.05)。结论小剂量甘露醇在急性中、重症脑卒中救治中,可减少不良反应,改善神经功能缺损,提高临床疗效及生活质量水平,具有重要的研究意义。Objective To analyze the clinical effect of treating acute moderate and severe cerebral apoplexy with low-dose mannitol,and observe the incidence of adverse reactions and quality of life.Methods Retrospective analysis on January 1,2019 to December 30,2020,during the hospital emergency department were analyzed in 80 cases of acute,severe cerebral apoplexy patients,according to the mannitol therapy dose was divided into two groups,40 cases in each group,control group given(large dose)250 ml20%mannitol treatment,observation group was given(small doses)125 ml20%mannitol treatment,observation of two groups of adverse reactions,the treatment effect,life quality,etc.Results The total effective rate and the incidence of adverse reactions in the observation group were 92.50%and 20.00%,respectively,and those in the control group were 75.00%and 42.50%,respectively,with statistical significance(P<0.05).The patients were followed up for half a year to evaluate the quality of life of the patients.The total score of the observation group was(82.16±1.27)points,and that of the control group was(65.81±3.77)points,with statistical significance(P<0.05).Conclusion In the treatment of acute moderate and severe cerebral apoplexy,low-dose mannitol can reduce adverse reactions,improve neurological function defects,improve clinical efficacy and quality of life,which has important research significance.

关 键 词：急性中、重症脑卒中 甘露醇 不良反应 生活质量 

分 类 号：R743.3[医药卫生—神经病学与精神病学]