斑马鱼模型在血液系统肿瘤疾病中的研究进展  

Research progress of zebrafish model in hematologic tumor diseases

作　　者：杨宇妍 何超 张瑞 唐景峰[1,2] YANG Yu-yan;HE Chao;ZHANG Rui;TANG Jing-feng(Department of Bioengineering and Food,Hubei University of Technology,Wuhan 430068,China;HBUT National)

机构地区：[1]湖北工业大学生物工程与食品学院,湖北武汉430068 [2]湖北工业大学国家外专局/教育部细胞调控与分子药物学科创新

出　　处：《生物技术》2021年第4期402-409,共8页Biotechnology

基　　金：国家自然科学基金项目(32070726;32000523);湖北省杰青人才项目(2020CFA073)。

摘　　要：斑马鱼是一种新型脊椎类动物模型,现已广泛运用于人类相关疾病研究。其具有实验操作简单、适用于高通量药物和相关致病基因筛选以及遗传操作系统成熟等特点。斑马鱼作为一种理想的人类血液疾病模型,其造血系统与人类的造血系统在进化和功能上是一致的。该文以斑马鱼模型在研究血液系统肿瘤疾病中的优势为出发点,概述了斑马鱼血液系统肿瘤疾病模型的建立与应用,为研究血液肿瘤疾病的致病机理,以及抗血液肿瘤疾病药物筛选研究提供参考。Zebrafish is emerging as recognized vertebrate animal model,which has been widely used in human disease research.The research advantages of this model include external fertilization,suitable for high throughput screening of drugs and related pathogenic genes,and susceptibility to genetic manipulation.As an ideal model of human blood disease,the hematopoietic system of zebrafish is consistent with the human hematopoietic system in terms of evolution and function.The article takes the advantagse of the zebrafish models on tumor blood system diseases as a starting point to summarize the establishment and application of zebrafish tumor blood system diseases model,this will provide a reference for related research of studying blood tumor disease pathogenesis,as well as in anti tumor blood diseases drug screening.

关 键 词：斑马鱼 动物模型 血液肿瘤疾病 药物筛选 

分 类 号：R-332[医药卫生]