射频消融术对良性甲状腺瘤患者甲状腺功能及HSP70蛋白表达的影响  

Effect of Radiofrequency Ablation on Thyroid Function and HSP70 Protein Expression in Patients with Benign Thyroid Tumors

作　　者：王恒[1] 伍军[1] WANG Heng;WU Jun(The First Affiliated Hospital of Henan University of Science and Technology,Luoyang,471000)

机构地区：[1]河南科技大学第一附属医院,471000

出　　处：《实用癌症杂志》2021年第8期1281-1284,1304,共5页The Practical Journal of Cancer

摘　　要：目的观察射频消融术(RFA)应用在良性甲状腺瘤(TT)中的价值,重点分析RFA对患者甲状腺功能及热休克蛋白70(HSP70)表达的影响。方法选取69例良性TT患者为研究对象,通过随机数字表法分为对照组(n=35)及观察组(n=34),对照组患者接受传统甲状腺切除术;观察组患者实施RFA治疗;均获得6个月随访结果;比较两组术后6个月肿瘤缩小情况;于术前、术后6个月比较两组甲状腺功能[游离甲状三碘原氨酸(FT3)、促甲状腺激素(TSH)、游离甲状腺素(FT4)];术前、术后即刻比较HSP70蛋白表达情况;记录两组并发症发生情况。结果观察组术后6个月结节体积小于对照组,结节缩小率(VRR)高于对照组(P<0.05);术后6个月,两组FT3、FT4、TSH较术前无明显变化(P>0.05),且两组间各时点比较差异无统计学意义(P>0.05);观察组术后即刻中央区、边缘区HSP70蛋白表达与术前比较无显著差异(P>0.05),但过渡区HSP70蛋白表达高于术前,且高于对照组(P<0.05);对照组术前、术后即刻3个区域HSP70蛋白表达均无显著差异(P>0.05);两组并发症发生率比较差异无统计学意义(P>0.05)。结论RFA应用在良性TT患者中,可提高结节缩小率,不损伤患者甲状腺功能,利于提高过渡区HSP70蛋白表达,患者治疗后并发症少,应用价值高。Objective To observe the value of radiofrequency ablation(RFA)in benign thyroid tumors(TT),mainly to analyze the effects of RFA on thyroid function and heat shock protein 70(HSP70)expression of patients.Methods 69 patients with benign TT were selected as the research objects.Divided them into the control group(n=35)and the observation group(n=34)by the random number table method,patients in the control group received traditional thyroidectomy;patients in the observation group received RFA treatment;all obtained results of 6-month follow-up;compared the tumor shrinkage between the 2 groups 6 months after operation;before surgery and 6 months after surgery,compared the thyroid function of the 2 groups[free thyroxine(FT3),thyroid-stimulating hormone(TSH),free thyroxine(FT4)];compared the expression of HSP70 protein before and immediately after surgery;the complications of the 2 groups were recorded.Results The nodule volume of the observation group was smaller than that of the control group 6 months after operation,and the nodule volume reduction rate(VRR)was higher than that of the control group(P<0.05);6 months after operation,the FT3,FT4,and TSH of the 2 groups had no significant changes compared with those before operation(P>0.05).And compared each time point ratio between the 2 groups,the difference was not significant statistically(P>0.05);compared the expression of HSP70 protein in the central and marginal areas of the observation group immediately after operation with that before surgery,the difference was not significant(P>0.05).However,the expression of HSP70 protein in the transition zone was higher than that before surgery and higher than that of the control group(P<0.05);there was no significant difference in the expression of HSP70 protein in the three regions of the control group before and immediately after operation(P>0.05);compared the complication rate ratio between the 2 groups,the difference was not significant statistically(P>0.05).Conclusion The application of RFA in patients with benign TT ca

关 键 词：良性甲状腺瘤 射频消融术 甲状腺功能 热休克蛋白70 

分 类 号：R736.1[医药卫生—肿瘤]