促甲状腺激素治疗甲状腺癌的疗效及对生化和内分泌指标的影响  

Effect of Thyroid Stimulating Hormone in the Treatment of Thyroid Cancer and Its Influence on Biochemical and Endocrine Indicators

作　　者：董华 许丽颖[1] 李明[1] DONG Hua;XU Liying;LI Ming(The First Affiliated Hospital of Zhengzhou University,Zhengzhou,450052)

机构地区：[1]郑州大学第一附属医院,450052

出　　处：《实用癌症杂志》2021年第8期1285-1288,共4页The Practical Journal of Cancer

摘　　要：目的观察促甲状腺激素治疗甲状腺癌的疗效及对生化和内分泌指标的影响。方法选取行甲状腺切除术后的甲状腺癌患者62例,按照促甲状腺激素治疗方案分为两组,采用常规剂量治疗的30例作为对照组,采用抑制剂量治疗的32例作为观察组,随访12个月,比较两组患者的疗效及安全性,生化指标、内分泌指标和生存质量。结果随访12个月期间两组均无复发病例,观察组不良反应发生率显著低于对照组(P<0.05)。治疗前两组ALT、AST、ALB、ALP、TB差异均无统计学意义(P>0.05),治疗后观察组ALT、ALP、TB显著低于对照组,AST、ALB显著高于对照组,组间差异有统计学意义(P<0.05)。治疗前两组FT3、FT4、TSH差异均无统计学意义(P>0.05),治疗后观察组FT3、FT4水平显著高于对照组,TSH水平显著低于对照组,组间差异有统计学意义(P<0.05)。治疗前两组患者的QLQ-C30各维度评分比较差异均无统计学意义(P>0.05),治疗后两组以上各项评分均显著改善,并且观察组总体健康状况、躯体功能、情绪功能、社会功能维度评分均显著高于对照组(P<0.05),而组间角色功能、认知功能维度评分差异无统计学意义(P>0.05)。结论促甲状腺激素治疗甲状腺癌的疗效满意,并能够改善患者的生化和内分泌指标,采用抑制剂量治疗改善效果更佳,并且安全性好,提高了患者的生存质量,可以根据患者个体情况优先选择。Objective To observe the effect of thyroid stimulating hormone in the treatment of thyroid cancer and its influence on biochemical and endocrine indicators.Methods 62 patients with thyroid cancer who underwent thyroidectomy were selected and divided into 2 groups according to the thyroid-stimulating hormone treatment plan,30 cases treated with conventional doses were used as the control group and 32 cases treated with inhibitors as the observation group,followed up for 12 months,the efficacy and safety,biochemical indicators[alanine aminotransferase(ALT),aspartate aminotransferase(AST),albumin(ALB),alkaline phosphatase(ALP),total bilirubin(TB)],endocrine indicators[free triiodothyronine(FT3),free thyroxine(FT4),thyroid stimulating hormone(TSH)],quality of life[quality of life questionnare-core 30(QLQ-C30)score]of the 2 groups were compared.Results During the 12-month followed-up,there was no recurrence in both groups,and the incidence of adverse reactions in the observation group was significantly lower than that in the control group(P<0.05).Before treatment,there was no significant difference in ALT,AST,ALB,ALP and TB between the 2 groups(P>0.05),after treatment,ALT,ALP and TB in the observation group were significantly lower than those in the control group,and AST and ALB were significantly higher than those in the control group,the differences were statistically significant(P<0.05).There was no statistically significant difference in FT3,FT4 and TSH between the 2 groups before treatment(P>0.05),after treatment,the levels of FT3 and FT4 in the observation group were significantly higher than those in the control group,the TSH level was significantly lower than that of the control group,and the differences between the 2 groups were statistically significant(P<0.05).Before treatment,there was no significant difference in QLQ-C30 scores between the 2 groups(P>0.05),after treatment,the above scores of the 2 groups were significantly improved,and the observation group’s overall health,physical function,emotional f

关 键 词：甲状腺癌 促甲状腺激素 剂量 疗效 生化 内分泌 

分 类 号：R736.1[医药卫生—肿瘤]