化痰通络饮治疗风痰阻络型急性期中风临床研究  

Clinical Study on Huatan Tongluo Yin for Stroke of Wind-Phlegm Obstructing Collateral Type at Acute Stage

作　　者：李小红 王瑞生 LI Xiaohong;WANG Ruisheng

机构地区：[1]确山县人民医院神经内科,河南确山463200

出　　处：《新中医》2021年第17期75-78,共4页New Chinese Medicine

摘　　要：目的:观察化痰通络饮治疗风痰阻络型急性期中风的临床疗效及对脂代谢、血脂蛋白相关磷脂酶A2 (Lp-PLA2)、白细胞介素-18 (IL-18)水平的影响。方法:将98例中风患者采用随机数字表法分为观察组及对照组各49例。2组均予以常规西药治疗,观察组在此基础上予以化痰通络饮。比较2组治疗3周后的临床疗效,观察2组治疗前、治疗3周后神经运动功能缺损[美国国立卫生研究院卒中量表(NIHSS)]评分,脂代谢指标[总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)],以及血清炎性因子(Lp-PLA2、IL-18)水平变化。结果:治疗3周后,观察组临床疗效总有效率为91.84%,高于对照组75.51%,差异有统计学意义(P<0.05)。治疗3周后,2组NIHSS评分均较治疗前降低(P<0.05),观察组NIHSS评分低于对照组(P<0.05)。治疗3周后,2组TC、TG、LDL水平均较治疗前降低(P<0.05),观察组上述3项水平均低于对照组(P<0.05)。治疗3周后,2组血清Lp-PLA2、IL-18水平均较治疗前降低(P<0.05),观察组上述2项水平均低于对照组(P<0.05)。结论:现代常规疗法联合化痰通络饮治疗风痰阻络型急性期中风可有助于神经功能恢复,改善脂代谢,延缓颈动脉粥样硬化斑块进展,可作为中医药辅助治疗中风的有效手段。Objective:To observe the clinical effect of Huatan Tongluo yin for stroke of wind-phlegm obstructing collateral type at acute stage,and its effect on lipid metabolism,lipoprotein associated phospholipase A2(Lp-PLA2),interleukin-18(IL-18) levels. Methods:A total of 98 cases of patients with stroke were divided into the observation group and the control group according to the random number table method,49 cases in each group. Both groups were treated with routine western medicine,and the observation group was additionally treated with Huatan Tongluo yin. The clinical effect after three-week treatment was compared between the two groups. Before treatment and after three-week treatment,changes in the score of neuromotor deficit [National Institutes of Health Stroke Scale(NIHSS)], lipid metabolism indexes [total cholesterol(TC),triglyceride(TG),low density lipoprotein(LDL)],and levels of inflammatory factors(Lp-PLA2,IL-18) in serum were observed.Results:After three-week treatment,the total clinical effective rate was 91.84% in the observation group,higher than that of 75.51% in the control group,the difference being significant(P<0.05). After three-week treatment,NIHSS scores in the two groups were decreased when compared with those before treatment(P<0.05),and the score in the observation group was lower than that in the control group(P<0.05). After three-week treatment,levels of TC,TG and LDL in the two groups were decreased when compared with those before treatment(P<0.05),and the levels in the observation group were lower than those in the control group(P<0.05). After three-week treatment,levels of Lp-PLA2 and IL-18 in serum in the two groups were decreased when compared with those before treatment(P<0.05),and the levels in the observation group were lower than those in the control group(P<0.05). Conclusion:For patients with stroke of wind-phlegm obstructing collateral type at acute stage, Huatan Tongluo yin combined with modern routine therapy can help the recovery of nerve function,improvement of lipid metabolis

关 键 词：中风 脑卒中 风痰阻络证 化痰通络饮 脂代谢 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R255.2[医药卫生—临床医学]