累及腭扁桃体的淋巴瘤44例临床病理分析  

Clinicopathological analysis of 44 cases of tonsillar lymphoma

作　　者：赵晓丽[1] 金玉兰[2] 王志强 邢莉[1] 张勇[1] 刘红刚[1] Zhao Xiaoli;Jin Yulan*;Wang Zhiqiang;Xing Li;Zhang Yong;Liu Honggang(Department of Pathology,Beijing Tongren Hospital,Capital Medical University,Beijing Key Laboratory of Head and Neck Molecular Diagnostic Pathology,Beijing 100730,China;Department of Pathology,Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing 100006,China)

机构地区：[1]首都医科大学附属北京同仁医院病理科/头颈部分子病理诊断北京市重点实验室,北京100730 [2]首都医科大学附属北京妇产医院病理科,北京100006

出　　处：《中国医刊》2021年第10期1117-1121,共5页Chinese Journal of Medicine

基　　金：北京市医管局扬帆计划(ZYLX201814)。

摘　　要：目的探讨腭扁桃体淋巴瘤的临床病理特点及各亚型的诊断要点。方法回顾性分析2005年6月至2015年1月首都医科大学附属北京同仁医院收治的44例扁桃体淋巴瘤患者的临床病理学特征。结果44例患者中,男19例,女25例,年龄29~93岁,平均(60.84±10.21)岁,中位年龄58岁。其中弥漫大B细胞淋巴瘤23例(1例为双打击淋巴瘤,MYC+/BCL-6^(+)基因异位),套细胞淋巴瘤4例(其中原位套细胞淋巴瘤1例,母细胞型套细胞淋巴瘤1例,经典型套细胞淋巴瘤2例),黏膜相关淋巴组织结外边缘区B细胞淋巴瘤3例,自然杀伤细胞/T细胞淋巴瘤5例,外周T细胞淋巴瘤-非特指型4例,滤泡性淋巴瘤2例,血管免疫母细胞性T细胞淋巴瘤1例,霍奇金淋巴瘤2例。结论在累及腭扁桃体的淋巴瘤中,非霍奇金淋巴瘤远多于霍奇金淋巴瘤。非霍奇金淋巴瘤中以B细胞淋巴瘤为主,尤以弥漫大B细胞淋巴瘤最多见(53.5%)。对于少见类型,免疫组化染色结合间期荧光原位杂交检测可提高病理诊断分型的准确性。Objective To summarize the clinicopathological features of different types of tonsil lymphoma,and to conclusion their diagnosis key points.Method From June 2005 to January 2015,patients diagnosed as tonsillar lymphoma in the Pathology Department of Beijing Tongren Hospital affiliated to Capital Medical University were retrospectively analyzed.Result There were 19 male and 25 female cases in 44 patients.The age range was 29-93 years old,the mean age was(60.84±10.21)years old.There were 23 cases of diffuse large B-cell lymphoma(DLBCL)(including one double hit lymphoma with ectopic MYC+/BCL-6+gene),4 cases of mantle cell lymphoma(MCL),3 cases of mucosa-associated lymphoid tissue lymphoma(MALT),5 cases of NK/T cell lymphoma,4 cases of peripheral T-cell lymphoma,non-specific type(PTCL-NOS),2 cases of follicular lymphoma(FL),1 case angioimmunoblastic T-cell lymphoma(AITL)and 2 cases of Hodgkin’s lymphoma(HL)respectively.Conclusion In lymphoma involving tonsil,non-Hodgkin’s lymphoma(NHL)is much more than HL.B cell lymphoma was predominant in NHL,of which the DLBCL was common(53.5%).For rare types,immunohistochemical staining combined with interphase fluorescence in situ hybridization(FISH)can improve the accuracy of pathological diagnosis and typing.

关 键 词：淋巴瘤 腭扁桃体 诊断 病理 预后 

分 类 号：R362[医药卫生—病理学]