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作 者:吴朝阳[1] 王生淋 沈荣凯[1] 陈飞[1] 林建华[1] 朱夏[1] 张真真[2] WU Zhaoyang;WANG Shenglin;SHEN Rongkai;CHEN Fei;LIN Jianhua;ZHU Xia;ZHANG Zhenzhen(Department of Orthopaedics,The First Affiliated Hospital of Fujian Medical University,Fuzhou 350005,China;Department of Pathology,The First Affiliated Hospital of Fujian Medical University,Fuzhou 350005,China)
机构地区:[1]福建医科大学附属第一医院骨科,福州350005 [2]福建医科大学附属第一医院病理科,福州350005
出 处:《肿瘤防治研究》2021年第9期859-863,共5页Cancer Research on Prevention and Treatment
基 金:福建省自然科学基金(2018J01168);福建省卫生健康中青年骨干人才培养项目资助计划(2019-ZQN-55)。
摘 要:目的探讨骨肉瘤软组织肿块骨化程度与患者临床病理特征的相关性。方法回顾性分析有软组织肿块的普通型骨肉瘤患者临床资料,包括Enneking分期、化疗敏感度、总生存期和转移出现后的生存时间。影像学评估软组织肿块内成骨情况,病理形态学上评估骨样基质占比。结果本研究共纳入符合要求的189例患者。EnnekingⅢB期患者中无成骨型、部分成骨型、成骨型分别占30.2%、9.6%和6.3%,无成骨型的骨肉瘤有更高的初诊转移率(P<0.05);无成骨型、部分成骨型、成骨型的化疗有效率分别为60.5%、59.6%和31.3%,成骨型的普通型骨肉瘤化疗敏感度更差(P<0.05);无成骨型的骨肉瘤总生存期短于部分成骨型或成骨型骨肉瘤(P<0.05);成骨型骨肉瘤转移后的生存时间长于无成骨型骨肉瘤(P=0.078)。结论在普通型骨肉瘤中,软组织肿块内的骨化程度与肿瘤的外科分期、化疗敏感度和预后相关,对患者化疗与手术时机的个体化选择可能有指导价值。Objective To investigate the association between the osteogenic differentiation in the soft tissue lump and the clinicopathological characteristics of osteosarcoma patients.Methods We retrospectively reviewed the clinical data of conventional osteosarcoma patients with soft tissue lumps,including Enneking stages,chemotherapy sensitivity,overall survival and post-metastatic survival time.The ossification level in soft tissue lumps was assessed by imaging and the proportion of osteoid matrix was assessed by pathological examination.Results A total of 189 cases were included in this study.In patients with Enneking IIIB,non-osteoblastic,partially osteoblastic and osteoblastic types accounted for 30.2%,9.6%and 6.3%,respectively.Non-osteoblastic osteosarcoma patients had a higher rate of initial metastasis(P<0.05);Chemotherapy efficiency of non-osteoblastic,partially osteoblastic and osteoblastic types were 60.5%,59.6%and 31.3%,respectively.The osteoblastic osteosarcoma held the worst rate of chemotherapy sensitivity(P<0.05).The overall survival of non-osteoblastic osteosarcoma was shorter than those of partially osteoblastic and osteoblastic types(P<0.05).Post-metastatic survival time of osteoblastic osteosarcoma was longer than that of non-osteoblastic osteosarcoma(P=0.078).Conclusion For conventional osteosarcoma,the osteogenesis level in soft tissue lumps is related to the surgical stage,chemotherapy sensitivity and prognosis of tumors,which may provide guidance for the individual decision regarding chemotherapy and surgery timing on patients.
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