定量磁化率成像在肝豆状核变性诊断中的应用  

The utility of quantitative susceptibility mapping in the diagnosis of Wilson′s disease

作　　者：袁相振 王晓平[1] Yuan Xiangzhen;Wang Xiaoping(Department of Neurology,Tongren Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200336,China)

机构地区：[1]上海交通大学医学院附属同仁医院神经内科,200336

出　　处：《中华神经科杂志》2021年第9期885-888,共4页Chinese Journal of Neurology

基　　金：国家自然科学基金(81671103)。

摘　　要：早期诊断和治疗是改善肝豆状核变性的预后、减少致残的关键。常规磁共振序列很难发现肝豆状核变性脑部的早期病变,特别是对于临床前期患者。定量磁化率成像是近年来新开发的磁共振后处理技术,对脑部磁性金属的沉积十分敏感。定量磁化率成像能够对肝豆状核变性基底节区金属沉积进行定量分析,有望成为肝豆状核变性早期诊断和病情评估的影像学技术。Early diagnosis and treatment is the key to improve the prognosis and reduce the disability of Wilson′s disease.Conventional magnetic resonance imaging sequences are difficult to detect early brain lesions in Wilson′s disease,especially in preclinical patients.Quantitative susceptibility mapping(QSM)is a recently developed magnetic resonance post-processing technique,which is very sensitive to magnetic metal deposition in the brain.QSM can be used for quantitative analysis of metal deposition in the basal ganglia of Wilson′s disease and is expected to be an imaging technique for early diagnosis and condition assessment of Wilson′s disease.

关 键 词：肝豆状核变性 定量磁化率成像 神经影像 诊断 

分 类 号：R742.4[医药卫生—神经病学与精神病学]