GM3抗体阳性吉兰-巴雷综合征一例  

Guillain-Barrésyndrome with GM3 antibody positive:a case report

作　　者：蔡浩[1] 王艳[1] 周玉颖[1] Cai Hao;Wang Yan;Zhou Yuying(Department of Neurology,Tianjin Huanhu Hospital,Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases,Tianjin 300350,China)

机构地区：[1]天津市环湖医院神经内科,天津市脑血管与神经变性重点实验室,300350

出　　处：《中华神经科杂志》2021年第9期945-948,共4页Chinese Journal of Neurology

摘　　要：吉兰-巴雷综合征是一种自身免疫性疾病,其发病被认为与神经节苷脂抗体的出现密切相关,而抗单唾液酸神经节苷脂GM3抗体既往报道较少。文中报道1例GM3抗体阳性相关的吉兰-巴雷综合征患者。患者为58岁女性,主因“双下肢无力10 d,右眼睑闭合不全8 d,左眼睑闭合不全伴头晕1 d”就诊。血清抗GM3抗体阳性,予丙种球蛋白治疗后症状好转。Guillain-Barrésyndrome is an autoimmune disease,and its pathogenesis is believed to be closely related to the appearance of ganglioside antibodies,while GM3 ganglioside antibodies have been reported rarely.This article reports a case of Guillain-Barrésyndrome associated with GM3 antibody positive.The patient was a 58-year-old female.The chief complaint was"weakness of both lower limbs for 10 days,incomplete closure of the right eyelid for eight days,and incomplete closure of the left eyelid with dizziness for one day".The serum anti-GM3 antibody was positive,and her symptoms improved after treatment with gamma globulin.

关 键 词：GM3抗体 吉兰-巴雷综合征 诊断 治疗 

分 类 号：R745.43[医药卫生—神经病学与精神病学]