抗谷氨酸脱羧酶抗体相关神经免疫病的临床表型与研究进展  

Progress in clinical phenotype and pathogenesis of neuroimmunological diseases associtated with anti-glutamic acid decarboxylase antibody

作　　者：柏琳 任海涛[1] 关鸿志[1] Bai Lin;Ren Haitao;Guan Hongzhi(Department of Neurology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Beijing 100730,China)

机构地区：[1]中国医学科学院北京协和医院神经科,100730

出　　处：《中华神经科杂志》2021年第9期963-967,共5页Chinese Journal of Neurology

基　　金：首都临床特色应用研究与成果推广基金(Z161100000516094)。

摘　　要：抗谷氨酸脱羧酶(GAD)抗体与僵人综合征、小脑性共济失调、边缘性脑炎及颞叶癫痫等多种神经免疫综合征相关。文中阐述抗GAD抗体相关神经免疫病的临床表型及抗GAD抗体致病机制的研究进展,以期对该病诊治有所帮助。Antibodies to glutamic acid decarboxylase(GAD)have been associated with several neurological syndromes,including stiff-person syndrome,cerebellar ataxia and epilepsy.This article critically reviews the main clinical characteristics and the evidence on the pathogenicity of GAD antibodies.

关 键 词：谷氨酸脱羧酶 僵人综合征 小脑共济失调 边缘叶脑炎 癫痫 

分 类 号：R741[医药卫生—神经病学与精神病学]