健脾益气方治疗慢性萎缩性胃炎临床疗效  

Effect of Jianpi Yiqi Decoction on chronic atrophic gastritis

作　　者：贾靖 徐甜甜 张毅[1] 汪洋[2] JIA Jing;XU Tiantian;ZHANG Yi;WANG Yang(Department of Gastroenterology,Huizhou Third People's Hospital,Huizhou,516000,China;Department of Gastrointestinal Surgery,Huizhou Third People's Hospital)

机构地区：[1]惠州市第三人民医院消化内科,广东惠州516000 [2]惠州市第三人民医院胃肠外科

出　　处：《中国中西医结合消化杂志》2021年第8期575-579,共5页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

摘　　要：目的:观察中药健脾益气方治疗慢性萎缩性胃炎(CAG)的临床疗效。方法:将110例CAG患者按照随机数字表法分为2组,每组55例,对照组予以四联疗法,观察组在对照组治疗基础上应用中药健脾益气方,疗程均为12周。比较2组治疗前后中医证候评分、胃镜评分和病理评分,并比较2组治疗前后血清蛋白酶原(PG)Ⅰ、PGⅡ、核转录因子-κB(NF-κB)、环氧合酶-2(COX-2)、白细胞介素-8(IL-8)水平和PGⅠ/PGⅡ值,并比较2组治疗总有效率。结果:治疗后观察组主证、次证评分均低于对照组(P<0.05);黏膜色泽、血管透见度、黏膜隆起、黏膜质地评分和腺体萎缩、肠上皮化生、异型增生积分均低于对照组(P<0.05),血清NF-κB、PGⅠ、PGⅡ水平及PGⅠ/PGⅡ值均高于对照组(P<0.05),血清COX-2、IL-8水平均低于对照组(P<0.05),治疗总有效率高于对照组(P<0.05),差异均有统计学意义。结论:健脾益气方有效缓解中医证候,调节胃蛋白酶原水平,改善胃黏膜病变程度,控制疾病进展,治疗CAG效果确切,其机制可能与调节血清NF-κB、COX-2、IL-8水平有关。Objective: To observe the clinical efficacy of Jianpi Yiqi Decoction in the treatment of chronic atrophic gastritis(CAG). Methods: One hundred and ten patients with CAG were randomly divided into two groups, with 55 cases in each group. The control group were given quadruple therapy, and the observation group were given Jianpi Yiqi Decoction on the basis of the control group. The course of treatment was for 12 weeks. The TCM syndrome score, gastroscope score and pathological score were compared between the two groups before and after treatment, and the serum levels of Pepsinogen(PG)Ⅰ, PGⅡ, Nuclear transcription factor NF-κB(NF-κB), Cyclooxygenase-2(COX-2), Interleukin-8(IL-8) level and value of PGⅠ/PGⅡ were compared between the two groups before and after treatment, and the total effective rate of the two groups was compared. Results: After treatment, the scores of main syndrome and secondary syndrome of the observation group were lower than those of the control group(P<0.05);The scores of mucosal color, vascular permeability, mucosal eminence, mucosal texture, glandular atrophy, intestinal metaplasia and dysplasia of the observation group were lower than those of the control group(P<0.05);The levels of serum NF-κB, PGⅠ, PGⅡand PGⅠ/PG Ⅱ of the observation group were higher than those of the control group(P<0.05);The levels of serum COX-2 and IL-8 of the observation group were lower than those in the control group(P<0.05) The total effective rate of the treatment group was higher than that of the control group(P<0.05). The differences were statistically significant. Conclusion: Jianpi Yiqi Decoction can effectively relieve TCM syndrome, regulate pepsinogen level, improve the degree of gastric mucosal lesions, control the progress of the disease, and it has definite effect on CAG. Its mechanism may be related to the regulation of serum NF-κB, COX-2 and IL-8 levels.

关 键 词：慢性萎缩性胃炎 中药 健脾益气方 机制 

分 类 号：R573.3[医药卫生—消化系统]