高血压脑出血患者血清TNF-α IL-6及VEGF的表达及意义  

The Expression and Significance of TNF-αIL-6 and VEGF in Serum of Patients with Hypertensive Intracerebral Hemorrhage

作　　者：刘思洋[1] 苏彬[1] 吴建龙[1] 梅赞 齐迎松 王学文[1] 李斌斌[2] 王婷婷 张金利 高继刚 LIU Siyang;SU Bin;WU Jianlong(The Central Hospital of Chengde,Hebei Cheng 067000,China)

机构地区：[1]河北省承德市中心医院,河北承德067000 [2]承德护理职业学院,河北承德067000

出　　处：《河北医学》2021年第9期1460-1464,共5页Hebei Medicine

基　　金：2020年承德市科学技术研究与发展计划,(编号:202006A157)。

摘　　要：目的:观察并分析高血压脑出血(hypertensive cerebral hemorrhage,HICH)患者血清中肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)及血管内皮生长因子(VEGF)的含量对高血压脑出血患者预后的影响。方法:选取承德市中心医院2018年8月至2020年8月收治的HICH患者96例作为观察组,并同时选取同期健康体检者30例作为对照组。同时将观察组按照出血量多少分为两组,出血量≥30mL组42例,<30mL组54例,并按照预后状态分为4组,死亡患者组8例,GCS评分3-8分24例,9-12分33例,GCS13-14分36例。采用酶联免疫吸附(ELISA)法检测HICH患者及健康体检者血清中TNF-α、IL-6及VEGF水平,并分析不同组别间HICH患者血清TNF-α、IL-6和VEGF含量的变化情况。结果:观察组血清TNF-α、IL-6及VEGF的含量明显高于对照组(P<0.05),出血量≥30mL组患者血清TNF-α、IL-6及VEGF的含量明显高于出血量<30mL组(P<0.05),并且预后状态越差患者血清中TNF-α、IL-6及VEGF的含量越高,各组之间TNF-α、IL-6及VEGF含量的变化具有统计学意义(P<0.05)。结论:高血压脑出血后血清中TNF-α、IL-6及VEGF的含量可能对患者的预后有影响。Objective:To observe and analyze the impact on the prognosis of the serum levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and vascular endothelial growth factor(VEGF)in patients with hypertensive cerebral hemorrhage(HICH).Methods:96 HICH patients admitted to Chengde Central Hospital from August 2018 to August 2020 were selected as the observation group,and 30 healthy controls during the same period were selected as the control group.At the same time,the observation group was subgrouped into 2 groups according to the amount of blood loss,42 cases in the blood loss≥30mL group,54 cases in the<30mL group,and also subgrouped into 4 groups according to the prognosis status,8 cases in the death group,24 cases in the GCS score 3-8 group,33 cases in the 9-12 group,36 cases in GCS13-14 group.Enzyme-linked immunosorbent assay(ELISA)was used to detect serum TNF-α,IL-6 and VEGF levels in HICH patients and healthy subjects,and to analyze the changes in serum TNF-α,IL-6 and VEGF levels in HICH patients among different groups.Results:The levels of serum TNF-α,IL-6 and VEGF in the observation group were significantly higher than those in the control group(P<0.05).The levels of serum TNF-α,IL-6 and VEGF in the blood loss≥30ml group were significantly higher than those in<30ml group(P<0.05),and the worse the prognosis,the higher the serum TNF-α,IL-6 and VEGF levels,and the changes in TNF-α,IL-6 and VEGF levels among the groups are statistically significant(P<0.05).Conclusion:The levels of TNF-α,IL-6 and VEGF in serum after hypertensive intracerebral hemorrhage may affect the prognosis of patients.

关 键 词：高血压性颅内出血 肿瘤坏死因子-Α 白细胞介素-6 血管内皮生长因子 

分 类 号：R743.34[医药卫生—神经病学与精神病学]