血清IGF-I HGF水平与脑胶质瘤术后低分割放疗患者预后的相关性研究  

Correlation between Serum IGF-I and HGF Levels and Prognosis of Patients with Hypofractionated Radiotherapy after Gliomas Surgery

作　　者：时彩艳 刘峰 卢宏全 黄国定 SHI Caiyan;LIU Feng;LU Hongquan(Hainan Western Central Hospital,Hainan Shanzhou 571700,China)

机构地区：[1]海南西部中心医院肿瘤内科放疗组,海南儋州571700

出　　处：《河北医学》2021年第9期1477-1482,共6页Hebei Medicine

基　　金：海南省卫生计生行业科研项目,(编号:1801320712A2028)。

摘　　要：目的:分析血清类胰岛素增长因子1(IGF-1)、肝细胞生长因子(HGF)表达与脑胶质瘤术后低分割放疗患者预后(病死)的关系。方法:选取2016年1月至2017年1月于我院手术且术后接受低分割放疗的53例脑胶质瘤患者,全部患者均于术后3~4周开始接受低分割放疗,18~2.0Gy/次,共54~60Gy。依据放疗后3年内预后(病死)情况分为预后不良组与预后良好组,调查两组一般资料、检测实验室指标并比较,重点分析血清IGF-1、HGF表达与患者预后的关系。结果:全部53例患者,放疗后接受为期3年的随访,病死25例,病死率为47.17%;预后不良患者血清VEGF、TGF-β、IGF-1及HGF水平均高于预后良好组(P<0.05);经回归分析结果显示,血清VEGF、TGF-β、IGF-1及HGF过表达均是脑胶质瘤术后低分割放疗患者预后不良的风险因子(OR>1,P<0.05);绘制ROC曲线,血清VEGF、TGF-β、IGF-1及HGF水平单独及联合预测脑胶质瘤术后低分割放疗患者预后不良(病死)的AUC均>0.80,且以各指标对应cut-off值为221.885pg/mL、42.205ng/L、111.080ng/mL、898.495μg/L时,预测价值最佳;相关性分析结果显示,脑胶质瘤术后低分割放疗患者血清IGF-I水平与HGF水平之间呈正相关(r>0,P<0.05)。结论:脑胶质瘤患者术后低分割放疗实施前血清IGF-I、HGF过表达与放疗后预后不良有关。Objective:To analyze the relationship between the expression of serum insulin-like growth factor 1(IGF-1)and hepatocyte growth factor(HGF)and prognosis(mortality)of patients with hypofractionated radiotherapy after gliomas surgery.Methods:53 patients with gliomas who underwent low-dose radiotherapy after operation and received surgery in our hospital from January 2016 to January 2017 were selected.And all patients received low-dose radiotherapy 3~4 weeks after operation,1.8~2.0 Gy/time,a total of 54~60 Gy.According to the prognosis(death from illness)within 3 years after radiotherapy,the patients were divided into a poor prognosis group and a good prognosis group,investigated the general data of the two groups,tested and compared laboratory indicators,the relationship between serum IGF-1 and HGF expression and prognosis of patients was mainly analyzed.Results:All 53 patients were followed up for 3 years after radiotherapy,25 were died of illness,and the mortality rate was 47.17%;the serum VEGF,TGF-β,IGF-1 and HGF levels in the poor prognosis patients were higher than the good group(P<0.05);The results of regression analysis showed that VEGF,TGF-β,IGF-1 and HGF were all the risk factors of poor prognosis in patients with hypofractionated radiotherapy after gliomas(OR>1,P<0.05);the ROC curve was drawn,VEGF,TGF-β,IGF-1 and HGF levels alone and in combination predicted the AUC of poor prognosis in patients with low segment radiotherapy after operation were all>0.80,the best prediction value could be obtained when the cut-off value of each index were 221.885pg/ml,42.205ng/l,111.080ng/ml and 898.495μg/l;the correlation analysis showed that there was a positive correlation between serum IGF-I and HGF level in patients with low segment radiotherapy after gliomas(r>0,P<0.05).Conclusion:The overexpression of serum IGF-I and HGF before hypofractionated radiotherapy is associated with poor prognosis after radiotherapy in patients with glioma after operation.

关 键 词：脑胶质瘤 低分割放疗 预后 类胰岛素增长因子1 肝细胞生长因子 

分 类 号：R739.41[医药卫生—肿瘤]