精神分裂症患者血清NCAM TrkB BDNF表达水平与临床症状的关系  

Relationship Between Serum NCAM TrkB BDNF Expression Levels and Clinical Symptoms in Patients with Schizophrenia

作　　者：廖东升 阿怀红 李少华 高春元 沈君 王红军 LIAO Dongsheng;A Huaihong;LI Shaohua(The Third People's Hospital of Qinghai Province,Qinghai Xining 810007,China)

机构地区：[1]青海省第三人民医院,青海西宁810007 [2]湖北省武汉市第五医院精神科,湖北武汉430000

出　　处：《河北医学》2021年第9期1503-1508,共6页Hebei Medicine

基　　金：湖北省卫生健康委科研项目,(编号:WJ2019F026)。

摘　　要：目的:检测精神分裂症患者血清神经细胞粘附分子(NCAM)、酪氨酸激酶受体B(TrkB)、脑源性神经营养因子(BDNF)的表达情况,并探究其表达水平与患者临床症状的相关性。方法:选取2018年11月至2020年8月就诊的精神分裂症患者70例为精神分裂症组,同期选取在本院体检中心进行常规体检的健康人群70例作为对照组。采用酶联免疫吸附(ELISA)法检测血清NCAM、TrkB、BDNF的表达水平,采用阳性和阴性综合征量表(PANSS)评分对患者的临床症状进行评定。采用Pearson法分析精神分裂症患者血清NCAM、TrkB、BDNF表达水平与PANSS评分的相关性;并对影响精神分裂症的相关因素采用Logistic回归分析;研究对象工作特征曲线(ROC)评估血清NCAM、TrkB、BDNF表达水平对精神分裂症患者的诊断价值。结果:精神分裂症组血清NCAM、TrkB、BDNF表达水平均显著低于对照组(P<0.05)。精神分裂症患者PANSS总分为(78.67±7.51)分,阳性症状评分为(29.38±4.25)分,阴性症状评分为(26.72±5.96)分,一般病理症状评分为(22.57±6.20)分。精神分裂症患者血清NCAM、TrkB、BDNF水平与PANSS总分及阳性症状评分均呈负相关(P<0.05)。血清NCAM、TrkB、BDNF低表达是影响精神分裂症发生的独立危险因素(P<0.05)。血清NCAM、TrkB、BDNF诊断精神分裂症的AUC分别为0.863、0.788、0.885,截断值分别为47.773μg/mL、42.727ng/mL、29.487pg/mL,此时对应灵敏度分别为67.1%、65.7%、84.3%,特异性分别为87.1%、78.6%、74.3%。结论:精神分裂症患者血清中NCAM、TrkB、BDNF表达水平明显降低,且与临床症状严重程度呈负相关,可能参与参与精神分裂症的发生及发展。Objective:To detect the expression of neural cell adhesion molecule(NCAM),tyrosine kinase receptor B(TrkB)and brain-derived neurotrophic factor(BDNF)in patients with schizophrenia,and to explore the correlation between their expression levels and clinical symptoms.Methods:Seventy schizophrenic patients from August 2018 to August 2020 were selected as the schizophrenia group,at the same time,70 healthy people who had routine physical examination in the physical examination center of our hospital were selected as the control group.Enzyme linked immunosorbent assay(ELISA)was used to detect the expression levels of NCAM,TrkB and BDNF in serum.The positive and negative syndrome scale(PANSS)was used to evaluate the clinical symptoms.Pearson method was used to analyze the correlation between serum NCAM,TrkB,BDNF expression levels and PANSS score;and Logistic regression analysis was used to analyze the related factors of schizophrenia;receiver operating characteristic curve(ROC)was used to evaluate the diagnostic value of serum NCAM,TrkB and BDNF levels in patients with schizophrenia.Results:The serum levels of NCAM,TrkB and BDNF in schizophrenia group were significantly lower than those in control group(P<0.05).The total score of PANSS was(78.67±7.51),and the positive symptom score was(29.38±4.25),and the negative symptom score was(26.72±5.96),and the general pathological symptom score was(22.57±6.20).Serum NCAM,TrkB and BDNF levels were negatively correlated with total score and positive symptom score of PANSS(P<0.05).The low expression of NCAM,TrkB and BDNF was an independent risk factor of schizophrenia(P<0.05).The AUC of serum NCAM,TrkB and BDNF in the diagnosis of schizophrenia was 0.863,0.788 and 0.885 respectively,and the cut-off value was 47.773μg/mL,42.727 ng/mL and 29.487 pg/mL,respectively,the corresponding sensitivity was 67.1%,65.7%,84.3%,and the specificity was 87.1%,78.6%and 74.3%,respectively.Conclusion:The expression levels of NCAM,TrkB and BDNF in the serum of schizophrenics are significantly redu

关 键 词：精神分裂症 神经细胞粘附分子 酪氨酸激酶受体 脑源性神经营养因子 阳性和阴性综合征量表 

分 类 号：R749.3[医药卫生—神经病学与精神病学]