盐酸安罗替尼二线治疗老年小细胞肺癌的有效性和安全性观察  

Effectiveness and safety of anlotinib hydrochloride second-line treatment on small cell lung cancer in elderly patients

作　　者：王宁军[1] 马银杰 高业博 薛鹏 高音[1] 周磊[1] 朱世杰[1] Wang Ningjun;Ma Yinjie;Gao Yebo;Xue Peng;Gao Yin;Zhou Lei;Zhu Shijie(Department of Oncology,Wangjing Hospital of China Academy of Chinese Medical Science,Beijing 100102,China)

机构地区：[1]中国中医科学院望京医院肿瘤科,北京100102

出　　处：《中国医药》2021年第9期1325-1328,共4页China Medicine

基　　金：国家自然科学基金(81573915)。

摘　　要：目的观察盐酸安罗替尼在老年小细胞肺癌患者中二线治疗的有效性和安全性。方法选择2018年6月至2020年6月在中国中医科学院望京医院肿瘤科住院治疗的28例确诊为广泛期小细胞肺癌的老年患者为研究对象。在一线治疗进展后予以盐酸安罗替尼口服进行二线治疗。通过观察治疗后的客观有效率(ORR)、疾病控制率(DCR)及不良反应,评估盐酸安罗替尼在老年小细胞肺癌患者中二线治疗的有效性及安全性。结果28例患者服用盐酸安罗替尼进行二线治疗后的ORR为28.6%(8/28),DCR为60.7%(17/28)。不良反应包括高血压、白细胞减少、凝血功能异常、肝肾功能异常、胃肠道反应、乏力、口腔黏膜炎、腹泻、蛋白尿等,以0~Ⅱ级为主,按需予以对症处理后缓解,严重不良反应发生率低。结论盐酸安罗替尼在老年小细胞肺癌患者的二线治疗中效果较好,不良反应可控,可以考虑作为不能耐受化疗的老年小细胞肺癌患者的二线治疗选择。Objective To observe the effectiveness and safety of anlotinib hydrochloride for second-line treatment on small cell lung cancer in elderly patients.Methods From June 2018 to June 2020,28 elderly patients with extensive stage small cell lung cancer in Department of Oncology,Wangjing Hospital of China Academy of Chinese Medical Science were selected.They were treated with anlotinib hydrochloride orally for second-line therapy after first-line treatment progress.The effectiveness and safety of anlotinib hydrochloride orally for second-line therapy on elderly patients with small cell lung cancer were evaluated by observing the objective response rate(ORR),disease control rate(DCR)and adverse reactions.Results The ORR and DCR of the 28 patients were28.6%(8/28)and 60.7%(17/28)respectively by oral anlotinib hydrochloride for second-line treatment.Adverse effects included hypertension,leucocytopenia,coagulation dysfunction,abnormal liver and kidney function,gastrointestinal reaction,fatigue,oral mucositis,diarrhea,proteinuria and so on.The adverse effects were mostly grade 0-Ⅱ,the patients were relieved after symptomatic treatment,and the incidence of serious adverse reactions was low.Conclusions Anlotinib hydrochloride has a good effect for second-line treatment on elderly patients with small cell lung cancer,and the adverse reactions are controllable.It can be considered as a second-line treatment option for elderly patients with small cell lung cancer who cannot tolerate chemotherapy.

关 键 词：小细胞肺癌 广泛期 盐酸安罗替尼 老年患者 

分 类 号：R734.2[医药卫生—肿瘤]