益生菌联合奥替溴铵对腹泻型肠易激综合征患者疗效及对血清CRP水平影响  

Effect of probiotics combined with otilonium bromide in treatment of diarrhea irritable bowel syndrome and influence on serum CRP level

作　　者：周雅蓉 谭雨晴 郑亚 郜莉娜[4] 李强[3] Zhou Yarong;Tan Yuqing;Zheng Ya;Gao Lina;Li Qiang(Lanzhou University First Clinical Medical School,Lanzhou 730000,Gansu,China;Lanzhou University Second Clinical Medical School,Lanzhou 730030,Gansu,China;Depatment of Gastroenterology,the First Hospital of Lanzhou University,Lanzhou 730000,Gansu,China;Laboratory Medical Center of Lanzhou University Second Hospital,Lanzhou 730030,Gansu,China)

机构地区：[1]兰州大学第一临床医学院,甘肃兰州730000 [2]兰州大学第二临床医学院,甘肃兰州730030 [3]兰州大学第一医院消化科,甘肃兰州730000 [4]兰州大学第二医院检验医学中心,甘肃兰州730030

出　　处：《生物医学转化》2021年第3期83-87,共5页Biomedical transformation

基　　金：兰州市科技发展指导性计划项目:(2019-ZD-52);兰州大学大学生创新创业计划项目(20210060084,20210050054)。

摘　　要：目的评估益生菌(酪酸梭菌活菌胶囊)联合奥替溴铵对腹泻型肠易激综合征(Diarrhea Irritable Bowel Syndrome,IBS-D)患者疗效及对血清CRP水平的影响。方法共纳入93例患者,随机分为试验组和对照组,分别给予酪酸梭菌活菌胶囊联合奥替溴铵及奥替溴铵治疗,疗程8周;观察不同方案对患者的疗效,不良反应等指标,血清CRP水平变化。结果患者大便频次与腹痛严重程度与血清CRP水平相关,具有统计学差异(分别ρ=0.773,P=0.000;ρ=0.734,P<0.001);治疗后试验组患者大便频次,大便性状恢复正常时间及腹痛缓解时间明显优于对照组,差异有统计学意义(分别P<0.001,P<0.002,P<0.003)且试验组患者血清CRP降低幅度大于对照组(P<0.004);试验组总有效率(93.62%)高于对照组(76.09%),差异有统计学意义(χ^(2)=5.586,P=0.018);试验组患者症状缓解程度越高,其CRP水平越低,二者呈负相关,具有统计学意义(ρ=-0.410,P=0.004);两组间不良反应无统计学差异(P>0.05)。结论IBS-D患者中血清CRP水平与其症状严重程度相关;给予益生菌(酪酸梭菌活菌胶囊)联合奥替溴铵方案,能够有效缓解患者症状,改善病情,且血清CRP水平随之下降,可作为疗效判定指标之一。Objective To evaluate the clinical efficacy of probiotics(Clostridium butyricum)combined with Otilonium bromide in treatment of diarrhea irritable bowel syndrome(IBS-D)and influence on serum CRP level.Methods A total of 93 patients were randomly divided into test group and control group,treated for 8 weeks with Clostridium butyricum combined with Otilonium bromide and Otilonium bromide alone,respectively.The efficacy,adverse reactions,and the serum CRP level between the two groups were evaluated.Results There was a significant correlation between the frequency of defecation and the severity of abdominal pain as well as the level of serum CRP(ρ=0.773,P=0.000;ρ=0.734,P<0.001,respectively).After treatment,the defecation freqency,stool characteristics and abdominal pain in the test group were significantly better than those in the control group(P<0.001,P<0.002,P<0.003,respectively),and the test group patients had a larger decrease of serum CRP level than that in the control group(P<0.004).The total effective rate of the test group(93.62%)was higher than that of the control group(76.09%)(χ2=5.586,P=0.018).There existed a negative correlation between the symptoms and the level of CRP in the test group(ρ=-0.410,P=0.004).There was no statistical difference in adverse reactions between the two groups(P>0.05).Conclusion The level of serum CRP in IBS-D patients is related to the severity of their symptoms.The probiotics(Clostridium butyricum)combined with Otilonium bromide can effectively alleviate the symptoms and improve the condition of patients,and the serum CRP level will decrease accordingly,which could be used as one of indicators for efficacy.

关 键 词：益生菌 腹泻型肠易激综合征 血清CRP 

分 类 号：R574.4[医药卫生—消化系统]