大环内酯类抗菌药物致长QT综合征的研究进展  

Research progress in long QT syndrome caused by macrolides

作　　者：于正阳 唐赛康 韩鑫 张昊川 金景玉[1] YU Zheng-yang;TANG Sai-kang;HAN Xin;ZHANG Hao-chuan;JIN Jing-yu(Department of Pharmacology,School of Pharmacy,Qingdao Medical College,Qingdao University,Qingdao Shandong 266073;Medical College,Qingdao University,Qingdao Shandong 266071)

机构地区：[1]青岛大学青岛医学院-药学院药理学系,山东青岛266073 [2]青岛大学医学部,山东青岛266071

出　　处：《中南药学》2021年第9期1871-1876,共6页Central South Pharmacy

摘　　要：大环内酯类抗菌药物引发的长QT综合征是一种严重的药物不良反应,能引发致命的心律失常和猝死。之前的研究认为,延迟整流钾电流是导致此类药物不良反应发生的基础。随着近年来研究的深入,晚钠电流、诸多胞内信号通路和多种临床因素亦被发现在长QT综合征的发生发展中发挥了复杂作用。本文对大环内酯类抗菌药物致长QT综合征的发生机制和影响其发生的相关临床因素进行了简要归纳,为新药的安全性筛查提供了相关理论基础,并为临床安全应用此类药物提供了重要参考。Long QT syndrome caused by macrolides is a severe adverse reaction,which can induce mortal arrhythmia and sudden cardiac death.Previous studies suggest that delayed rectifier potassium current is the fundamental mechanism of this adverse reaction.With the in-depth research in recent years,late sodium current,multiple cell signaling pathways and several clinical factors have also been found to play complex roles in the occurrence and development of long QT syndrome.In this article,the mechanism and relative clinical factors of the long QT syndrome caused by macrolides are summarized to provide theoretical basis for the safe screening of new drugs and for the safe clinical use of macrolides.

关 键 词：长QT综合征 尖端扭转型室性心动过速 大环内酯类 

分 类 号：R96[医药卫生—药理学]