不同OCT分型的视网膜静脉阻塞性黄斑水肿与血小板参数的关系  

Relationship between retinal vein obstructive macular edema and platelet parameters in different OCT types

作　　者：蒋菲菲 周利晓[1] 齐若[1] 关丽珂 吕梁[1] 盛风格 Fei-Fei Jiang;Li-Xiao Zhou;Ruo Qi;Li-Ke Guan;Liang Lyu;Feng-Ge Sheng(Department of Ophthalmology, the Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China)

机构地区：[1]郑州大学第五附属医院眼科,中国河南省郑州市450052

出　　处：《国际眼科杂志》2021年第10期1816-1819,共4页International Eye Science

基　　金：河南省医学科技攻关计划项目(No.SB201903012)。

摘　　要：目的:探究不同OCT分型的视网膜静脉阻塞(RVO)性黄斑水肿(ME)与血小板参数的关系。方法:回顾性研究。收集2016-12/2021-02首诊于郑州大学第五附属医院眼科的RVO患者126例126眼,其中视网膜中央静脉阻塞(CRVO)患者51眼,视网膜分支静脉阻塞(BRVO)患者75眼,未合并ME(Non-ME)患者31眼,合并ME患者95眼。根据OCT形态将ME分为弥漫性视网膜增厚(DRT)组26眼、黄斑囊样水肿(CME)组30眼、浆液性视网膜脱离(SRD)组39眼,收集不同组别患者的血小板参数包括血小板计数(PLT)、血小板平均体积(MPV)、血小板压积(PCT)和血小板体积分布宽度(PDW)并进行统计学分析。结果:ME组MPV及CMT高于Non-ME组(均P<0.001),SRD组患者的MPV高于DRT组及CME组(均P<0.001),DRT组与CME组间MPV比较无差异(P=0.526),SRD组CMT明显高于DRT组与CME组(P<0.001),CMT在DRT组与CME组之间比较无差异(P=0.190)。结论:MPV在不同OCT分型的RVO性ME患者中存在差异,活化的血小板与SRD发生和发展可能密切相关。AIM:To investigate the relationship between platelet parameters and macular edema(ME)in retinal vein occlusion(RVO)patients with different OCT types.METHODS:Retrospective study.A total of 126 eyes in 126 patients with RVO were enrolled in the ophthalmology department of the Fifth Affiliated Hospital of Zhengzhou University from December 2016 to February 2021,among whom,51 eyes with central retinal vein occlusion(CRVO)were included,branch retinal vein occlusion(BRVO)included 75 eyes,31 eyes without ME(non-ME)and 95 eyes with ME.According to the morphology of OCT,ME was divided into 26 eyes of diffuse retinal thickening(DRT),30 eyes of cystoid macular edema(CME)and 39 eyes of serous retinal detachment(SRD),the platelet parameters of patients with different groups including platelet count(PLT),mean platelet volume(MPV),plateletcrit(PCT)and platelet distribution width(PDW)were collected and statistical analysis were performed.RESULTS:The MPV value and CMT value of ME group was higher than that of Non-ME group(all P<0.001),the MPV value of SRD group was higher than that of DRT group and CME group(all P<0.001),but there was no statistically significant difference in MPV between DRT group and CME group(P=0.526),CMT in SRD group was significantly higher than that in DRT group and CME group(P<0.001),and there was no significant difference in CMT between DRT group and CME group(P=0.190).CONCLUSION:MPV has differences in patients with RVO ME with different OCT classifications,activated platelets may be closely related to the occurrence and development of SRD.

关 键 词：视网膜静脉阻塞性黄斑水肿 光学相干断层扫描 黄斑中心凹视网膜厚度 血小板平均体积 

分 类 号：R774.1[医药卫生—眼科]