胃肠道肿瘤精准治疗一体化研究体系的建设  

Construction of an integrated research system for precision treatment of gastrointestinal tumors

作　　者：蒋枋利 章程[1] 高静 沈琳[1] Fangli Jiang;Cheng Zhang;Jing Gao;Lin Shen(Department of Gastrointestinal Oncology,Key laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing),Peking University Cancer Hospital&Institute,Beijing 100142,China;Department of Central Laboratory,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Shenzhen 518116,China)

机构地区：[1]北京大学肿瘤医院暨北京市肿瘤防治研究所,消化肿瘤内科恶性肿瘤发病机制及转化研究教育部重点实验室,北京市100142 [2]国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院深圳医院中心实验室

出　　处：《中国肿瘤临床》2021年第17期865-869,共5页Chinese Journal of Clinical Oncology

基　　金：国家重点研发计划重大慢性非传染性疾病防控研究重点专项项目(编号:2017YFC1308900);第三批北京市属医学科研院所公益发展改革试点项目(编号:京医研2019-1)资助。

摘　　要：中国胃肠道肿瘤的发病率和死亡率较高,防治形势严峻。由于早筛意识差,多数患者确诊时疾病分期较晚。近年来,随着精准医疗的倡导与发展,如乳腺癌、肺癌、黑色素瘤、淋巴瘤等的精准治疗取得较大进展,但胃肠道肿瘤的精准治疗发展较为落后,主要原因在于其异质性高、分子靶点稀少、临床前研究模型缺乏、精准疗效监测和评效困难等。鉴于此,本课题组历经多年研究建立了“胃肠道肿瘤精准治疗一体化研究体系”,该体系涵盖样本库、临床前药物评价平台、临床转化研究平台和临床疗效精准动态监测模型,实现了“临床问题进入临床前研究平台探索”及“临床前成果回归至临床研究”的双向转化研究模式,直接推动了胃肠道肿瘤精准治疗发展。本文主要围绕该转化研究体系及其成功应用案例进行介绍,并对展望其未来发展方向。Given the severe situation in gastrointestinal cancerprevention and control,the incidence and mortality rates of gastrointestinal cancer in China have been reported to be very high.Moreover,due to the weak awareness of early screening,most patients with gastrointestinal cancers are diagnosed at advanced stages.With the advocacy and development of precision medicine in recent years,precision treatment of tumors,including breast cancer,lung cancer,melanoma,and lymphoma,has made great progress.However,precision medicine for gastrointestinal tumors is relatively backward owing to challenges in signature profiling,including high heterogeneity,few molecular targets,lack of preclinical research models,and difficulties in accurate efficacy monitoring and evaluation.Therefore,our team has established an integrated research system for the precision treatment of gastrointestinal tumors over the years,covering patients’sample database,preclinical drug evaluation platform,clinical transformation research platform,and accurate dynamic monitoring model of clinical efficacy.Notably,this system has realized the two-way transformation research mode of“clinical problems transfer into preclinical research platform”and“preclinical results return to clinical research”,which directly promote the development of precision treatment for gastrointestinal tumors.This review discusses our transformation research system,its successful application in gastrointestinal tumor cases,and its future direction of development.

关 键 词：胃肠道肿瘤 精准治疗 转化研究 平台体系 

分 类 号：R735[医药卫生—肿瘤]