近距离放疗调节抗肿瘤免疫效应的研究进展  

Research progress of brachytherapy in regulating anti-tumor immune effect

作　　者：李虎子(综述)[1] 赵路军(审校) Huzi Li;Lujun Zhao(Department of Oncology,First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,300193 Tianjin,China;Department of Radiotherapy,Tianjin Medical University Cancer Institute and Hospital,National Clinical Research Center for Cancer,Tianjin Key Laboratory of Cancer Prevention and Therapy,Tianjin’s Clinical Research Center for Cancer,Tianjin 300073,China)

机构地区：[1]天津中医药大学第一附属医院肿瘤科,天津市300073 [2]天津医科大学肿瘤医院放疗科,天津市“肿瘤防治”重点实验室,国家肿瘤临床医学研究中心

出　　处：《中国肿瘤临床》2021年第17期914-918,共5页Chinese Journal of Clinical Oncology

基　　金：天津市中医药重点领域科研项目(编号:2017003)资助。

摘　　要：近距离放射治疗(brachytherapy,BT),包括高剂量率BT(high-dose-rate BT,HDR-BT)和低剂量率BT(low-dose-rate BT,LDR-BT),不仅能控制局部病灶,还能诱发免疫原性肿瘤细胞死亡,通过抗原交叉递呈及T淋巴细胞的活化,激活机体抗肿瘤免疫效应。本文就BT诱导肿瘤细胞的死亡和免疫性抗原的释放、促进树突状细胞(dendritic cells,DCs)和T细胞的活化、调节淋巴细胞亚群,进而诱发的抗肿瘤免疫效应进行综述。Brachytherapy(BT),including high-and low-dose-rate BT,can control local tumor lesions,induce the death of immunogenic tumor cells,and activate the anti-tumor immune effect through cross-presentation of antigens and activation of T lymphocyte cells.In this manuscript,we review BT-induced immunogenic tumor cell death and release of antigens,maturation and activation of dendritic cells and T lymphocyte cells,and adjustment of lymphocyte subsets.Our aim is to clarify BT-induced anti-tumor immune effects and their possible mechanisms.

关 键 词：近距离放疗 免疫效应 高剂量率 低剂量率 远隔效应 

分 类 号：R730.55[医药卫生—肿瘤]