脑胶质瘤的突触机制研究进展  

Research progress in synaptic related mechanism of glioma

作　　者：叶立果 徐阳 袁凡恩 胡平 张春雨 包艳辉 陈谦学[1] 田道锋[1] Ye Liguo;Xu Yang;Yuan Fan′en;Hu Ping;Zhang Chunyu;Bao Yanhui;Chen Qianxue;Tian Daofeng(Department of Neurosurgery,Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院神经外科,430060

出　　处：《中华实验外科杂志》2021年第9期1841-1843,共3页Chinese Journal of Experimental Surgery

摘　　要：脑胶质瘤是颅内最常见的原发性恶性肿瘤,增殖和侵袭是其重要的特征,胶质瘤进展相关机制研究较多,但这些研究并未很好的转化为有效的治疗手段。最近,肿瘤突触相关机制的研究为探讨脑胶质瘤的生理学和病理学背后的特定分子机制提供了新的思路和理解,胶质瘤细胞中的肿瘤微管会和正常神经元形成功能性化学突触,神经元的电活动通过神经元胶质瘤突触结构激活肿瘤细胞间钙信号网络,导致多级细胞致癌信号级联和神经元细胞骨架重塑机制启动,进而促进胶质瘤细胞的增殖和侵袭。本文将围绕胶质瘤相关的突触机制研究作一综述,总结当前胶质瘤相关电生理机制领域的研究动态,以期为进一步的研究方向提供理论支持和指导。Glioma is the most common primary malignant tumor in the brain,while proliferation and invasion are its vital characteristics.There were many studies on the mechanisms of glioma progression,but these studies have not been well translated into effective treatment against tumors.The studies of tumor synaptic related mechanisms provided new ideas and understanding for exploring the specific molecular mechanisms behind the physiology and pathology of glioma.Functional chemical synapses form between normal neurons and the tumor microtubules in gliomas.The electrical activity of neurons activates the calcium signal network between tumor cells through the synaptic structure of gliomas,leading to the activation of multi-level cellular carcinogenic signal cascade and neuronal cytoskeleton remodeling mechanism,thus promoting the proliferation and invasion of glioma cells,and ultimately leading to tumor progression.In this review,we focus on the synaptic mechanism of glioma and summarize the trends of current research in the field of glioma-related electrophysiological mechanism,so as to provide theoretical support and guidance for further research in the future.

关 键 词：胶质瘤 发病机制 

分 类 号：R739.41[医药卫生—肿瘤]