那他霉素滴眼液与伏立康唑滴眼液治疗真菌性角膜炎的效果比较  

Effects of Natamycin Eye Drops and Voriconazole Eye Drops in the Treatment of Fungal Keratitis

作　　者：张小玉 付珂 ZHANG Xiaoyu;FU Ke(Department of Ophthalmology,the First Outpatient Department of Organs Directly under Henan Province/the First Hospital Directly under Henan Provincial People’s Hospital,Zhengzhou 450000,China;Department of Ophthalmology,the First Affiliated Hospital of Nanyang Medical College,Nanyang 473000,China)

机构地区：[1]河南省直属机关第一门诊部/河南省人民医院省直第一医院眼科,河南郑州450000 [2]南阳医学高等专科学校第一附属医院眼科,河南南阳473000

出　　处：《河南医学研究》2021年第27期5112-5115,共4页Henan Medical Research

摘　　要：目的比较那他霉素滴眼液与伏立康唑滴眼液治疗真菌性角膜炎的效果。方法选取2016年1月至2020年1月南阳医学高等专科学校第一附属医院收治的86例真菌性角膜炎患者作为研究对象,按随机数表法分为对照组与研究组,各43例。对照组接受伏立康唑滴眼液治疗,研究组接受那他霉素滴眼液治疗,比较两组治疗1个月后的临床效果、视力恢复情况、眼部严重程度评分及不良反应。结果治疗1个月后,研究组治疗有效率(95.35%)高于对照组(79.07%),差异有统计学意义(P<0.05)。治疗1个月后,研究组视力矫正率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组眼部严重程度评分比较,差异无统计学意义(P>0.05);治疗1个月后,两组眼部严重程度评分均下降,且研究组低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论相比于伏立康唑滴眼液,给予真菌性角膜炎患者那他霉素滴眼液治疗,更有利于提升患者的临床效果,提高患者视力矫正率,降低患者眼部严重程度评分。Objective To compare the effects of natamycin eye drops and voriconazole eye drops on fungal keratitis.Methods A total of 86 patients with fungal keratitis admitted to the First Affiliated Hospital of Nanyang Medical College from January 2016 to January 2020 were selected as research objects,and divided into a control group and a study group according to a random number table,with 43 cases in each group.The control group received voriconazole eye drops,and the study group received natamycin eye drops.The clinical effect,visual recovery,eye severity score,and adverse reactions of the two groups were compared after 1 month of treatment.Results After one month of treatment,the effective rate of treatment in the study group(95.35%)was higher than that of the control group(79.07%)(P<0.05).After one month of treatment,the rate of vision correction in the study group was higher than that of the control group(P<0.05).After one month of treatment,the eye severity scores of the two groups of patients were lower than before treatment,and the study group was lower than the control group(P<0.05),and there was no statistical difference in the incidence of adverse reactions between,the two groups(P>0.05).Conclusion Compared with voriconazole eye drops,the administration of natamycin eye drops to patients with fungal keratitis is more conducive to improving the clinical efficacy of patients,improving the rate of vision correction of patients,and reducing the severity of the eyes of patients.

关 键 词：真菌性角膜炎 那他霉素滴眼液 伏立康唑滴眼液 

分 类 号：R772.21[医药卫生—眼科]