利用PyMol软件绘图辅助血红蛋白立体结构教学  

Application of hemoglobin stereoscopic structure visualization in protein structure teaching

作　　者：李冀宏[1] 吕桂香[1] 马宁[1] 高旭[1] 彭亚会[1] LI Jihong;LYU Guixiang;MA Ning;GAO Xu;PENG Yahui(Department of Biochemistry and Molecular Biology,Harbin Medical University,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学生物化学与分子生物学教研室,哈尔滨150081

出　　处：《生命的化学》2021年第7期1417-1421,共5页Chemistry of Life

基　　金：黑龙江省高等教育教学改革(重点)项目(SJGZ20200109);哈医大基础医学院“课程思政”优秀示范课程项目(202101);黑龙江省教育科学规划重点课题(GJB1320181);教育部第二批医学院校二级学院“三全育人”教育试点项目(2019)。

摘　　要：血红蛋白是哺乳动物体内负责运输氧的结合蛋白,是由血红素和珠蛋白组成的异源四聚体。本研究以血红蛋白为例,探讨PyMol作为教学辅助软件,将蛋白立体结构进行可视化,在蛋白质结构教学中的应用。教师可以更加直观、立体、生动地向学生讲解蛋白质结构和功能相关的内容。学生课后可以通过此软件自主学习,提高学生学习的主动性、探索性,有助于加深学生对蛋白质结构和功能的理解。Hemoglobin is a kind of heterotetramer composed of heme and globin, which is responsible for transporting oxygen in mammals. Here hemoglobin is taken as an example to explore the application of PyMol as a teaching aid software to visualize the three-dimensional structure of protein in the teaching of protein structure. Teachers can explain protein structure and function to students more intuitively, stereoscopically and vividly. After class, students can learn independently through this software to improve their learning initiative and exploration ability. It is helpful for students to have a deep understanding of protein structure and function.

关 键 词：血红蛋白 立体结构 可视化 蛋白质结构 协同效应 

分 类 号：G642[文化科学—高等教育学] Q51-4[文化科学—教育学]