酒精性肝硬化腹水患者机体免疫相关细胞因子表达与病情进展、SBP发生的相关性探究  

Study on the correlation between the Expression of immunerelated cytokines and Disease Progression and SBP in Patients with alcoholic Cirrhosis and Ascites

作　　者：蒋刚健 陈庆丰 武文豪 黄德峰[2] JIANG Gangjian;CHEN Qingfeng;WU Wenhao;HUANG Defeng(Department of Laboratory Medicine,Luohe Central Hospital,Luohe Henan 462000,China;Department of Gastroenterology,Luohe Central Hospital,Luohe Henan 462000,China)

机构地区：[1]漯河市中心医院检验科,河南漯河462000 [2]漯河市中心医院消化内科,河南漯河462000

出　　处：《临床研究》2021年第10期28-30,共3页Clinical Research

摘　　要：目的探究酒精性肝硬化腹水患者机体免疫相关细胞因子表达与其病情进展,同时探究其与自发性细菌性腹膜炎(SBP)发生的相关性。方法回顾性分析2019年8月至2020年4月于漯河市中心医院就诊的60例酒精性肝硬化患者临床资料,根据肝功能Child-Pugh评分标准将其分为A组、B组、C组,每组20例,另选取20例同期体检的健康人群作为对照组。根据指标统计结果,采用多元Logistics回归分析对患者机体免疫相关细胞因子与其病情、SBP发生进行相关性。结果C组CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)水平低于A组、B组及对照组;B组CD3^(+)、CD4^(+)、CD8^(+)水平低于A组、对照组,差异均有统计学意义(P<0.05)。C组TNF-α、IL-4、IL-10、IL-13指标水平明显低于A组、B组、对照组;B组TNF-α、IL-4、IL-10、IL-13指标水平明显低于A组、对照组,差异均具有统计学意义(P<0.05)。经多元Logistic回归分析显示:CD3^(+)、CD4^(+)、CD8^(+)是患者病情进展及发生SBP的保护因素,TNF-α、IL-4、IL-10、IL-13是影响患者病情进展和发生SBP的独立危险因素(P<0.05)。结论精性肝硬化腹水患者机体免疫相关细胞因子表达水平与患者病情严重程度、SBP发生存在明显相关性,免疫相关细胞因子表达水平越低,肝硬化程度越严重,更容易发生SBP,应针对其免疫力水平进行药物干预,避免感染发生。Objective To investigate the correlation between the expression of immune related cytokines and the progression of alcoholic cirrhosis with ascites and the occurrence of spontaneous bacterial peritonitis(SBP).Methods The clinical data of 60 patients with alcoholic cirrhosis in Luohe central hospital from August 2019 to April 2020 were analyzed retrospectively.According to the Child-Pugh score,the patients were divided into group A,group B and group C with 20 cases in each group.In addition,20 healthy people with physical examination at the same time were selected as the control group.According to the statistical results,the multiple logistic regression analysis was used to analyze the correlation between the levels of immune-related cytokines and SBP.Results The levels of CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+)in group C were significantly lower than those in group A,group B and control group,and the levels of CD3^(+),CD4^(+)and CD8^(+)in group B were significantly lower than those in group A and control group(P<0.05).The levels of TNF-α,IL-4,IL-10 and IL-13 in group C were significantly lower than those in group A,group B and control group,and the levels of TNF-α,IL-4,IL-10 and IL-13 in group B were significantly lower than those in group A and control group(P<0.05).Multiple Logistic regression analysis showed that CD3^(+),CD4^(+)and CD8^(+)were the protective factors of SBP,and TNF-α,IL-4,IL-10 and IL-13 were the independent risk factors of SBP(P<0.05).Conclusion There is a significant correlation between the expression level of immune-related cytokines and the severity of SBP.The lower the expression level of immune-related cytokines is,the more severe the liver cirrhosis is,and SBP is more likely to occur.Drug intervention should be carried out according to its immunity level to avoid infection.

关 键 词：酒精性肝硬化腹水 免疫相关细胞因子 自发性细菌性腹膜炎 病情进展 

分 类 号：R575.2[医药卫生—消化系统]