口服姜胶囊或姜粉对癌症患者化疗相关性恶心呕吐临床疗效的系统评价  

The clinical efficacy of ginger in treating chemotherapy-induced nausea and vomiting in cancer patients:a systematic review

作　　者：翟田田 丁楠楠 赵亚芸[2] 裴露斯 金七妹[2] 高祝英[2] 杨雪梅[2] Zhai Tiantian;Ding Nannan;Zhao Yayun;Pei Lusi;Jin Qimei;Gao Zhuying;Yang Xuemei(College of Nursing,Lanzhou University,Lanzhou 730000,China;Department of Nursing,Second Hospital of Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学护理学院,730000 [2]兰州大学第二医院护理部,730000

出　　处：《中国实用护理杂志》2020年第25期1994-2000,F0003,共8页Chinese Journal of Practical Nursing

基　　金：国家自然基金面上项目(81770525);兰州大学第二医院萃英科技项目(CY2017-HL07)。

摘　　要：目的系统评价口服姜胶囊或姜粉对癌症患者化疗相关性恶心呕吐的临床疗效。方法计算机检索中国期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)、万方数据库、PubMed、EMbase、Web of Science、Cochrane Library数据库有关口服姜胶囊或姜粉对癌症患者化疗相关性恶心呕吐临床疗效的随机对照试验(RCT),并辅以其他检索方式,时间范围为建库至2019年7月。由2名研究者独立对纳入文献进行质量评价和资料提取,采用RevMan 5.3软件进行Meta分析。结果共纳入12篇文献,13项研究,共1105例患者。Meta分析结果显示,口服姜胶囊或姜粉能降低急性呕吐的发生率[相对危险度(RR)值为0.76,95%可信区间(CI)0.59~0.98,P<0.05]和呕吐的严重程度[平均差(MD)值为-0.79,95%CI-1.36~-0.23,P<0.01],包括急性呕吐的严重程度(MD值为-1.39,95%CI-2.72~-0.06,P<0.05)和延迟性呕吐的严重程度(MD值为-0.46,95%CI-0.82~-0.10,P<0.05),但在急性和延迟性恶心发生率和严重程度方面2组患者差异无统计学意义(P>0.05)。结论口服姜胶囊或姜粉是一种辅助治疗癌症患者化疗相关性恶心呕吐的方法,今后需要开展更多高质量的研究验证其临床疗效。Objective To systematically evaluate the clinical efficacy of oral ginger capsule or ginger powder in chemotherapy-induced nausea and vomiting in cancer patients.Methods Computers searched Chinese Journal Full-text Database(CNKI),China Biomedical Literature Database(CBM),Wanfang Database,PubMed,EMbase,Web of Science,and Cochrane Library about oral chemotherapy in patients with cancer ginger correlation clinical curative effect of nausea and vomiting randomized controlled trial,supplemented by other search methods,the time range was built until July 2019.Quality evaluation and data extraction were performed independently by two investigators,and Meta analysis was performed by RevMan5.3 software.Results A total of 12 articles and 13 studies were included,with a total of 1105 patients.Meta-analysis showed that oral ginger capsule or ginger powder reduced the incidence of acute vomiting(risk ratio value was 0.76,95%confidence interval was 0.59-0.98,P<0.05)and the severity of vomiting(mean difference value was-0.79,95%confidence interval was-1.36--0.23,P<0.01),including the severity of acute vomiting(mean difference value was-1.39,95%confidence interval was-2.72--0.06,P<0.05)and the severity of delayed vomiting(mean difference value was-0.46,95%confidence interval was-0.82--0.10,P<0.05).However,there was no significant difference between the two groups in the incidence and severity of acute and delayed nausea(P>0.05).Conclusions This study demonstrates that oral ginger capsule or ginger powder is a complementary treatment for chemotherapy-induced nausea and vomiting in cancer patients,and more high-quality studies are needed to validate its clinical efficacy in the future.

关 键 词：肿瘤 化疗 恶心呕吐 系统评价 

分 类 号：R730.5[医药卫生—肿瘤]