T cell metabolism in obesity and beyond:comments on‘DsbA-L deficiency in T cells promotes diet-induced thermogenesis through suppressing IFN-y production’  

作　　者：Haiyan Zhou Feng Liu 

机构地区：[1]National Clinical Research Center for Metabolic Diseases,Metabolic Syndrome Research Center,and Department of Metabolism and Endocrinology,The Second Xiangya Hospital of Central South University,Changsha 410011,China [2]Department of Pharmacology,University of Texas Health Science Center at San Antonio,San Antonio,TX 78229,USA

出　　处：《Journal of Molecular Cell Biology》2021年第5期389-391,共3页分子细胞生物学报（英文版）

基　　金：The work described was supported by grants from the National Natural Science Foundation of China(81730022 and 81600671);the National Key R&D Program of China(2018YFC2000100 and 2019YFA0801903);Natural Science Foundation of Hunan Province,China(2019JJ50867).

摘　　要：T cells have long been known as the core of adaptive immunity and play piv-otal roles in host defense(Zhu et al.,2010).There are two main types of T cells in our body,cytotoxic T cells(CD8^(+))and helper T(Th)cells(CD4^(+)),the latter comprised of Th1,Th2,Th17,and Treg subsets.Increasing evidence supports that metabolic reprogramming of T cells leads to dramatic changes in tissue microenvironments,which may alter whole-body energy homeostasis and metabolism,beyond their roles in adaptive immunity(Varanasi et al.,2020).

关 键 词：METABOLISM IMMUNITY 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]