Novel regulation of the eEF2K/eEF2 pathway:prospects of'PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation'  

作　　者：Yuqian Shen Junhai Han Zi Chao Zhang 

机构地区：[1]School of Life Science and Technology,Key Laboratory of Developmental Genes and Human Disease,Southeast University,Nanjing 210096,China [2]Co-innovation Center of Neuroregeneration,Nantong University,Nantong 226001,China

出　　处：《Journal of Molecular Cell Biology》2021年第5期392-394,共3页分子细胞生物学报（英文版）

基　　金：The described work was supported by the National Natural Science Foundation of China(81730034 to J.H.,31671045 to Z.C.Z.,and 81901287 to Shuting Xia);the Natural Science Foundation of Jiangsu Province(BK20170080 to Z.C.Z.);Guangdong Key Project(2018B030335001 to J.H.).

摘　　要：Protein synthesis involves initiation,elongation,and termination.A number of studies show that translation elongation is highly regulated and is the most energy-intensive process,which controls the efficiency and accuracy of protein synthesis.In the elongation process,eukaryotic elongation factor 2(eEF2)binds to the ribosome to induce its conformation change and promotes the translocation of the tRNAs by hydrolyzing guanosine triphosphate,which then allows the next AA-tRNA to enter the A site for translation elongation.The activity of eEF2 is negatively regulated by its kinase eEF2K that phosphorylates eEF2 at threonine-56(Thr56).

关 键 词：synthesis EF2 TRANSLATIONAL 

分 类 号：Q591.2[生物学—生物化学]