铑催化的吲哚与亚砜型叶立德的[4+2]环化反应构建二氢嘧啶并吲哚酮衍生物  

Rh(Ⅲ)-Catalyzed[4+2]Annulation of Indoles with Sulfoxonium Ylides for the Synthesis of Dihydropyrimidoindolone Derivatives

作　　者：舒赛 黄志斌[1] 陈宇杰 杨闪 蒋雅琦琪 张静宇 赵应声[1,2] Shu Sai;Huang Zhibin;Chen Yujie;Yang Shan;Jiang Yaqiqi;Zhang jingyu;Zhao Yingsheng(College of Chemistry,Chemical Engineering and Materials Science,Soochow University,Suzhou,Jiangsu 215123;School of Chemistry and Chemical Engineerings Henan Normal University,Xinxiang,Henan 453000)

机构地区：[1]苏州大学材料与化学化工学部,江苏苏州215123 [2]河南师范大学化学化工学院,河南新乡453000

出　　处：《有机化学》2021年第8期3171-3179,共9页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.21772139,21572149);江苏省高等学校自然科学基金重大基础研究(Nos.15KJA150006,17KJA150006);江苏省杰出青年自然科学基金(No.BK2018g0041);苏州科技基础设施项目(No.SZS2018201708);河南师范大学化学骨干特色学科开放基金;江苏高校优势学科建设工程资助项目.

摘　　要：报道了Rh(Ⅲ)催化的N-甲氧基-1H-吲哚-1-甲酰胺与亚砜型叶立德的选择性C(2)-H活化/环化反应.该方法为二氢嘧啶并吲哚酮衍生物的制备提供了一种新方法,产率中等至优良,具有反应条件简单温和,催化剂用量低,底物适应性广等特点.A Rh(Ⅲ)-catalyzed, regioselective C(2)-H activation/cyclization of N-methoxy-1 H-indole-1-carboxamides and sulfoxonium ylides was developed. This novel synthetic procedure afforded dihydropyrimido[1,6-a]indol-1(2 H)-ones in moderate to excellent yields. This reaction proceeds under simple and mild conditions with low catalyst loading and tolerates a wide range of substrates.

关 键 词：吲哚 亚砜型叶立德 环化反应 

分 类 号：O626[理学—有机化学]