m6A甲基化在妇科恶性肿瘤中的研究进展  

Research progress of m6A methylation in gynecological malignant tumors

作　　者：马龙 张宗峰[1] MA Long;ZHANG Zongfeng(Department of Gynecology and Obstetrics,the Second Affiliated Hospital of Harbin Medical University,Heilongjiang Harbin 150001,China)

机构地区：[1]哈尔滨医科大学附属第二医院妇产科,黑龙江哈尔滨150001

出　　处：《现代肿瘤医学》2021年第20期3658-3661,共4页Journal of Modern Oncology

基　　金：国家自然科学基金资助项目(编号:81671430)。

摘　　要：近年来大量研究表明表观遗传现象m6A甲基化与恶性肿瘤的发生发展密切相关,其通过甲基转移酶、去甲基酶及m6A结合蛋白影响mRNA的剪切、翻译及稳定性从而调控肿瘤细胞的增殖、分化及耐药性。随着m6A甲基化在恶性肿瘤方面研究的不断深入,其在宫颈癌、子宫内膜癌和卵巢癌等妇科恶性肿瘤中的相关作用机制也逐渐被发现。本文将对近年来m6A甲基化在宫颈癌、子宫内膜癌和卵巢癌等发病率较高的妇科恶性肿瘤中的相关研究进展作一综述,介绍甲基转移酶、去甲基酶及m6A结合蛋白通过对mRNA的作用修饰而调控肿瘤发生发展的机制。其相关研究结果亦将为妇科恶性肿瘤的预防和治疗提供新的检测方法和作用靶点。In recent years,a large number of studies have shown that the epigenetic phenomenon of m6A methylation is closely related to the occurrence and development of malignant tumors.It affects the shearing,translation and stability of mRNA through methyltransferase,demethylase and m6A binding protein,thus regulating the proliferation,differentiation and drug resistance of tumor cells.With the deepening of the research on the methylation of m6A in malignant tumors,its mechanism of action in cervical cancer,endometrial cancer,ovarian cancer and other gynecological malignancies has been gradually discovered.Therefore,this paper reviewed the recent research progress of m6A methylation in gynecological malignant tumors with high incidence of cervical cancer,endometrial cancer and ovarian cancer,and introduced the mechanism by which methyltransferase,demethylase and m6A binding protein regulate the occurrence and development of tumors by modifying the role of mRNA.The related research results will also provide new detection methods and targets for the prevention and treatment of gynecological malignant tumors.

关 键 词：N6-甲基腺嘌呤 m6A 表观遗传学 宫颈癌 子宫内膜癌 卵巢癌 

分 类 号：R737.3[医药卫生—肿瘤]