清肠温中方对缓解期溃疡性结肠炎的远期作用研究  

Study on Qingchang Wenzhong Decoction in the treatment of remission ulcerative colitis

作　　者：孙中美 陈晓伟[2] 胡立明[2] 王志斌[2] 史瑞[2] 姚玉璞[2] 毛堂友 谭祥[1] 丁庞华 李军祥[2] SUN Zhongmei;CHEN Xiaowei;HU Liming;WANG Zhibin;SHI Rui;YAO Yupu;MAO Tangyou;TAN Xiang;DING Panghua;LI Junxiang(Beijing University of Chinese Medicine,Beijing,100029,China;Department of Gastroenterology,Dongfang Hospital,Beijing University of Chinese Medicine)

机构地区：[1]北京中医药大学,北京100029 [2]北京中医药大学东方医院消化内科

出　　处：《中国中西医结合消化杂志》2021年第9期619-623,共5页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

基　　金：国家中医药管理局中医药传承与创新"百千万"人才工程(歧黄工程)岐黄学者(李军祥);北京中医药大学自主课题青年教师项目(No:2017-JYB-JS-089);北京丰台区卫生计生系统科研项目(No:2016-45)。

摘　　要：目的:观察清肠温中方对缓解期溃疡性结肠炎患者维持缓解、预防复发的疗效以及用药安全性,为临床广泛应用提供科学依据。方法:采用前瞻性研究的方法,纳入缓解期溃疡性结肠炎患者50例,予清肠温中方治疗(1剂/d),治疗1年,患者每2个月接受随访,填写中医证候积分量表、生存质量积分表。治疗满1年时接受肠镜检查,患者纳入研究时及治疗满1年时均行安全性检查。结果:接受清肠温中方治疗1年后,患者维持缓解率为81.4%。治疗期间,患者便溏、腹痛、腹胀、食少、肢体倦怠、神疲懒言的症状较治疗前明显改善(P<0.05或P<0.01);患者的生存质量包括肠道症状、社会能力、情感能力、全身症状较治疗前明显提高(P<0.05或P<0.01)。结论:清肠温中方能够有效维持缓解期溃疡性结肠炎的长期缓解,显著改善患者腹痛、便溏、腹胀、食少等临床症状,提高生存质量,且无明显不良反应。Objective:To observe the safety of Qingchang Wenzhong Decoction and its effect on clinical symptoms,disease activity and quality of life of patients with remission ulcerative colitis,and to provide scientific basis for its wide application in clinic.Methods:A prospective study of 50 patients with remission ulcerative colitis were treated with Qingchang Wenzhong Decoction for 1 year.During the study,the patients were followed-up every 2 months,and the Traditional Chinese Medicine(TCM)syndrome scale and inflammatory bowel disease questionnaire scale were filled out.The patients were examined by enteroscopy at the end of the 12 months of treatment,and the safety tests were performed when the patients were included in the study and at the end of the 12 months of treatment.Results:After one year’s treatment,81.4%of patients remained in remission.The symptoms of loose stools,abdominal pain,abdominal distension,less food,body burnout and mental fatigue were significantly improved(P<0.05 or P<0.01),and the quality of life including intestinal symptoms,social ability,emotional ability,systemic symptoms(P<0.05 or P<0.01).Conclusion:Qingchang Wenzhong Decoction effectively prevent the relapse of ulcerative colitis patients in remission stage,relieving the clinical symptoms,such as abdominal pain,loose stool,abdominal distension,less food,and improving the quality of life without obvious adverse reactions.

关 键 词：溃疡性结肠炎 缓解期 清肠温中方 远期疗效 

分 类 号：R574.62[医药卫生—消化系统]