腺苷2A受体在肝脏损伤中的作用研究进展  

Advances in the study of the role of adenosine 2A receptor in liver injury

作　　者：蔡玉立[1] 陈小琳[1] 易波[1] 李俊峰[1] 文重远[1] 江应安[2] Cai Yuli;Chen Xiaolin;Yi Bo;Li Junfeng;Wen Zhongyuan;Jiang Yingan(Department of Endocrinology,Renmin Hospital of Wuhan University,Wuhan 430060,China;Department of Infectious Disease,Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院内分泌科,武汉430060 [2]武汉大学人民医院感染科,武汉430060

出　　处：《中华肝脏病杂志》2021年第9期904-907,共4页Chinese Journal of Hepatology

基　　金：湖北省自然科学基金(2018CFB140)。

摘　　要：腺苷,作为一种内源性嘌呤核苷,广泛分布于全身各组织器官,与腺苷受体结合,调节多种重要的生物过程,其中腺苷2A受体与多种临床疾病的发生.发展都有着密切的关系。现主要综述腺苷2A受体在非酒精性脂肪性肝病.急性免疫性肝炎、肝脏缺血-再灌注损伤和肝纤维化等多种肝脏损伤中的作用研究进展,以期为上述疾病的防治研究提供新的策略。Adenosine,as an endogenous purine nucleoside,is widely distributed in various tissues and organs of the body.It binds to adenosine receptors to regulate a variety of important biological processes.Adenosine 2A receptors have a close relationship with the occurrence and development of various clinical diseases.This article reviews the research progress of adenosine 2 A receptors in non-alcoholic fatty liver disease,acute immune hepatitis,liver ischemia-reperfusion injury,liver fibrosis,etc.,in order to provide new research strategies for the prevention and treatment of these diseases.

关 键 词：肝脏 腺苷 腺苷2A受体 

分 类 号：R575[医药卫生—消化系统]