干细胞在神经免疫性疾病中的应用研究进展  

Clinical Application Study of Stem Cells in Neuroimmunologic Diseases

作　　者：王柳清 刘赞华 薛群[2] WANG Liu-qing;LIU Zan-hua;XUE Qun(Department of Neurology,Gaochun People’s Hospital,Nanjing 211300,China;Department of Neurology,the First Affiliated Hospital of Soochow University,Suzhou 215000,China)

机构地区：[1]南京市高淳人民医院神经内科,南京211300 [2]苏州大学附属第一医院神经内科,苏州215000

出　　处：《中国临床神经科学》2021年第5期590-596,共7页Chinese Journal of Clinical Neurosciences

摘　　要：近年来业内研究者对神经系统自身免疫性疾病谱和神经系统自身抗体谱的认识不断深入。干细胞具有自我更新和多向分化潜能,具有免疫调节和组织修复作用,可通过分泌细胞因子、调节T细胞等发挥免疫调节作用,成为神经系统免疫性疾病的新兴治疗方案之一,在动物实验和临床试验中,干细胞治疗在多发性硬化、重症肌无力等均显示出积极的治疗效果。文中就近年干细胞在神经免疫性疾病中的应用研究文献做综述。In recent two decades,people have a deeper understanding of nervous system autoimmune disease spectrum and nervous system autoantibody spectrum with the development of technology.Stem cells have the potential of self-renewal and multi-directional differentiation,and have the capacity with the function of immune regulation and tissue repair,which can play the role of immunomodulatory by secreting cytokines and regulating T cells,thus become a new treatment for nervous system immune diseases.However,in animal experiments and clinical trials,stem cell therapy had shown positive therapeutic effects in multiple sclerosis and myasthenia gravis.The application of stem cells in neuroimmune diseases were reviewed combined with recently literature.

关 键 词：干细胞 免疫调节 多发性硬化 间充质干细胞 造血干细胞 神经干细胞 

分 类 号：R746[医药卫生—神经病学与精神病学] Q189[医药卫生—临床医学]