两种不同螺纹设计的牙种植体在犬颌骨中骨结合的对比研究  

The effects of different thread designs on osseointegration of dental implants:a comparative experimental study in canine jaw

作　　者：刘成武 刘远翔 李志鹏[2] 刘泉[1] 武诗语 吴夏怡[1] 陈泽涛[2] 黄宝鑫[2] 陈卓凡[1] Liu Chengwu;Liu Yuanxiang;Li Zhipeng;Liu Quart;Wu Shiyu;Wu Xiayi;Chen Zetao;Huang Baoxin;Chen Zhuofan(Department of Zhujiang New Town Dental Clinic,Guanghua School of Stomatology,Hospital of Stomatology,Sun Yat-sen University&Guangdong Provincial Key Laboratory of Stomatology,Guangzhou 510623,China;Department of Oral Implantology,Guanghua School of Stomatology,Hospital of Stomatology,Sun Yat sen University&Guangdong Provincial Key Laboratory of Stomatology,Guangzhou 510055,China)

机构地区：[1]中山大学光华口腔医学院·附属口腔医院洙江新城门诊·广东省口腔医学重点实验室,广州510623 [2]中山大学光华口腔医学院·附属口腔医院口腔种植科·广东省口腔医学重点实验室,广州510055

出　　处：《中国口腔种植学杂志》2021年第4期226-231,共6页Chinese Journal of Oral Implantology

基　　金：国家自然科学基金(81970975,82001095)。

摘　　要：目的评价两种不同螺纹设计的牙种植体在比格犬下颌骨中不同时期的骨结合情况。方法选取纯种雄性比格犬4只,分别拔除双侧下颌第二前磨牙至第二磨牙,愈合12周。选择两种不同螺纹设计的牙种植体作为实验组和对照组,采取左右对照原则,每侧植入4颗相同种植体,埋入式愈合。术后2周和12周分别处死2只动物取材(n=8)。通过口内X线片和不脱钙硬组织切片进行放射线和组织学评估。结果X线片示两组种植体在不同时期的骨结合情况相似。组织学结果显示2周时植体与宿主骨主要为机械嵌合,种植体周围有少量新生骨形成;12周时种植体周围形成了大量矿化成熟的新生骨组织和骨小梁样结构。实验组和对照组种植体中段的骨结合率(bone-implant contact,BIC%)分别为(46.69±8.47)%和(36.71±13.72)%(2周),(67.27±7.46)%和(56.63±8.31)%(12周),两组间差异均无统计学意义。结论两种不同螺纹设计的牙种植体均能获得满意且相当的骨结合效果。Objective To evaluate the osseointegration of dental implants with different thread designs in the canine mandible.Methods Four male beagle dogs were selected.Bilateral mandibular premolars and molars(PM2-M2)were extracted and allowed to heal for 12 weeks.The test group was a newly-designed dental implant,and the control group was AstraTech OsseoSpeed^(TM)TX dental implant.Four implants were implanted(submerged healing)on each side with a split-mouth design.Two animals were sacrificed at 2 and 12 weeks after surgery,respectively(n=8).Intraoral digital X-ray images and non-decalcified hard tissue sections were used for radiological and histological evaluations.Results Radiological images showed similar bone healing in two groups at 2 and 12 weeks after surgery.The histological results showed that at 2 weeks,implants were mainly mechanically inbuilt into the host bone,and a small number of new bones were formed around implants.At 12 weeks,a large number of completely mineralized new bones with the trabecular-liked structure was formed around implants.The bone-implant contact(BIC%)of the test and control group were(46.69±8.47)%and(36.71±13.72)%at 2 weeks,(67.27±7.46)%and(56.63±8.31)%at 12 weeks,respectively,and the difference between groups was not statistically significant.Conclusions Two dental implants with different thread shapes can achieve satisfactory and comparable osseointegration.

关 键 词：牙种植体 螺纹设计 骨结合 延期种植 比格犬 

分 类 号：R783.6[医药卫生—口腔医学]