血清炎性因子对脑胶质瘤的诊断价值  

Diagnostic value of serum inflammatory factors for glioma

作　　者：李丽丽[1] 孙琪云 赵嫱 LI Lili;SUN Qiyun;ZHAO Qiang(Department of Laboratory Medicine,Beijing Fengtai Youanmen Hospital,Beijing 100069,China;Department of Oncology,Beijing Fengtai Youanmen Hospital,Beijing 100069,China)

机构地区：[1]北京丰台右安门医院检验科,北京100069 [2]北京丰台右安门医院肿瘤科,北京100069

出　　处：《癌症进展》2021年第16期1682-1685,共4页Oncology Progress

摘　　要：目的探讨血清炎性因子对脑胶质瘤的诊断价值。方法将280例脑胶质瘤患者作为观察组,另选取100例同时期健康体检者作为对照组,检测所有研究对象术前1天和术后血清炎性因子[白细胞介素-6(IL-6)、淀粉样蛋白A(SAA)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)]水平,比较术前和术后不同病理分级脑胶质瘤患者血清炎性因子水平,并分析单独检测和联合检测各项炎性因子对脑胶质瘤的诊断价值。结果术前Ⅰ级脑胶质瘤患者血清IL-6、SAA、CRP水平最低,且血清IL-6、SAA、CRP水平随病理分级增加逐渐升高,Ⅰ级脑胶质瘤患者TNF-α水平最高,且血清TNF-α水平随病理分级增加逐渐降低,差异均有统计学意义(P﹤0.05)。术前,Ⅰ~Ⅱ级脑胶质瘤患者血清IL-6、SAA、CRP水平均明显低于Ⅲ~Ⅳ级患者,TNF-α水平明显高于Ⅲ~Ⅳ级患者,差异均有统计学意义(P﹤0.05);术后,Ⅰ~Ⅱ级及Ⅲ~Ⅳ级脑胶质瘤患者血清IL-6、SAA、CRP、TNF-α水平均较术前降低,差异均有统计学意义(P﹤0.05)。单独检测IL-6、SAA、TNF-α、CRP诊断脑胶质瘤的准确度较低,分别为71.79%、80.71%、76.07%、80.36%,联合检测诊断脑胶质瘤的准确度较高为95.36%,明显高于各指标单独检测(P﹤0.05)。结论联合检测脑胶质瘤患者血清IL-6、SAA、TNF-α、CRP水平能够有效诊断脑胶质瘤的病理分级,有效反映脑胶质瘤的肿瘤恶性程度。Objective To investigate the diagnostic value of serum inflammatory factors for glioma.Method A total of 280 patients with glioma were enrolled as the observation group,and another 100 patients with healthy physical examination during the same period were selected as the control group.The serum inflammatory factors[interleukin-6(IL-6),serum amyloid A(SAA),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP)]levels one day before and after the operation were detected in all subjects.The levels of serum inflammatory factors in patients with different pathological grades of glioma before and after surgery were compared,and the diagnostic value of individual detection and combined detection of various inflammatory factors in glioma was also analyzed.Result Before the surgery,the serum levels of IL-6,SAA,and CRP in patients with grade Ⅰ glioma was the lowest,and the levels of serum IL-6,SAA,and CRP gradually increased with the increase of pathological grade.In contrast,the level of TNF-α in patients with grade Ⅰ glioma was the highest,and the level of serum TNF-α gradually decreased with the increase of pathological grade,the differences were statistically significant(P<0.05).Before surgery,the serum levels of IL-6,SAA,and CRP in patients with grade Ⅰ-Ⅱ glioma were significantly lower than those in grade Ⅲ-Ⅳ,and the level of TNF-α was significantly higher than that in patients with grade Ⅲ-Ⅳ,the differences were statistically significant(P<0.05).After the surgery,the serum levels of IL-6,SAA,CRP,and TNF-α in patients with grade Ⅰ-Ⅱ and grade Ⅲ-Ⅳ glioma were lower than those before the operation,and the differences were statistically significant(P<0.05).The accuracy of the detection of IL-6,SAA,TNF-α,and CRP alone in the diagnosis of glioma were low,and the value were 71.79%,80.71%,76.07%,and 80.36%,respectively.The accuracy of combined detection in the diagnosis of glioma reached 95.36%,which was significantly higher than the individual testing indicators(P<0.05).Conclusion The combine

关 键 词：血清炎性因子 脑胶质瘤 诊断价值 

分 类 号：R739.41[医药卫生—肿瘤]