RNA m^(5)C甲基化在肿瘤发生发展中的调控作用  

Role of m^(5)C RNA methylation in cancer

作　　者：徐英杰 文雪倩 冯璐瑶 田鑫[1] XU Ying-jie;WEN Xue-qian;FENG Lu-yao;TIAN Xin(Dept of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China)

机构地区：[1]郑州大学第一附属医院药学部,河南郑州450052

出　　处：《中国药理学通报》2021年第10期1352-1355,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 31870809);河南医学科技攻关省部共建重大项目(No SBGJ202001007)。

摘　　要：m^(5)C甲基化作为一种重要的表观遗传修饰,存在于几乎所有类型的RNA中。RNA m^(5)C修饰在RNA的翻译、稳定性、出核以及DNA损伤修复等生物学过程中发挥了重要作用。近年来越来越多的研究发现,m^(5)C修饰在肿瘤的发生及进展中发挥着重要的调控作用,且m^(5)C相关修饰酶的表达和预后密切相关。该文主要针对m^(5)C修饰的生物学功能以及在肿瘤发生发展中的作用进行综述。The epigenetic modification 5-methylcytosine exists in almost all types of RNA.Functionally RNA m^(5)C modification plays an important role in several physiological processes including RNA translation,stability,nuclear export,and DNA damage-repair.In recent years,many studies have found that m^(5)C modification can regulate the occurrence and development of tumors,and the expression of m^(5)C modifying enzymes is closely related to prognosis.In this review,we probed to the biological functions of m^(5)C and its role in tumorigenesis and development.

关 键 词：RNA甲基化 5甲基胞嘧啶(m^(5)C) 转录后调控 表观遗传学 肿瘤 靶向治疗 

分 类 号：R-05[医药卫生] R342.2