NSCLC外周血循环肿瘤细胞水平检测及其与TNM分期、预后的关系  

Expression characteristics of peripheral blood circulating tumor cells in NSCLC and their correlation with TNM staging and prognosis

作　　者：白力允[1] 谢静 白力丹 邢俊领[1] 赵红丹[1] 宋士军[1] BAI Liyun;XIE Jing;BAI Lidan;XING Junling;ZHAO Hongdan;SONG Shijun(Department of Oncology,the Third Affiliated Hospital of Xinxiang Medical College,Henan Xinxiang 453000,China;Department of Diagnostics,School of Clinical,Sanquan College of Xinxiang Medical College,Henan Xinxiang 453000,China)

机构地区：[1]新乡医学院第三附属医院肿瘤内科,河南新乡453000 [2]新乡医学院三全学院临床学院诊断教研室,河南新乡453000

出　　处：《现代肿瘤医学》2021年第19期3380-3385,共6页Journal of Modern Oncology

基　　金：河南省新乡市科技攻关计划项目(编号:CXGG17033)。

摘　　要：目的:分析非小细胞肺癌(non-small cell lung cancer, NSCLC)外周血循环肿瘤细胞(circulating tumor cells, CTC)表达特点及其与国际抗癌联盟肿瘤通用分期(tumor node metastasis, TNM)及预后的关系。方法:采集我院胸外科收治的NSCLC患者82例,选取肺良性疾病30例作为良性组及30名正常志愿者作为对照组,入院后均完成外周血CTC检测,比较NSCLC外周血CTC与良性组、对照组之间的差异;比较不同病理类型、TNM分期、不同预后NSCLC患者CTC阳性率,筛选NSCLC预后影响因素。结果:NSCLC组CTC阳性率高于良性组与对照组(P<0.05),良性组、对照组组间对比差异无统计学意义(P>0.05);不同病理类型NSCLC患者CTC阳性率比较差异无统计学意义(P>0.05);不同TNM分期NSCLC患者CTC阳性率比较差异有统计学意义(P<0.05),各分期CTC阳性率比较:Ⅲa期>Ⅱ期>Ⅰ期;CTC阴性NSCLC患者随访中位无病生存时间(disease free survival,DFS)长于阳性组,复发、转移率低于阳性组(P<0.05);有吸烟史、CTC阳性、高TNM分期、伴淋巴结转移的NSCLC患者中位DFS低于无吸烟史、CTC阴性、低TNM分期、无淋巴结转移的NSCLC患者(P<0.05);Cox回归分析显示:TNM分期、CTC、淋巴结转移均为影响NSCLC患者中位DFS的相关因素(P<0.05)。结论:NSCLC外周血CTC阳性率较高,且与TNM分期、淋巴结转移共同影响患者预后。Objective:To analyze the expression characteristics of peripheral blood circulating tumor cells(CTC)in non-small cell lung cancer(NSCLC)and their relationship with tumor node metastasis(TNM)stages and prognosis.Methods:Eighty-two patients with NSCLC treated in the department of thoracic surgery were enrolled in the study.30 patients with benign pulmonary disease were selected as the benign group and 30 normal volunteers were selected as the control group.All of the subjects completed detection of peripheral blood CTC after admission.Peripheral blood CTC in patients with NSCLC was compared with the benign group and the control group.The positive rates of CTC in patients with different pathological types of NSCLC,patients at different TNM stages and those with different prognosis were compared,and the prognostic factors of NSCLC were screened.Results:The positive rate of CTC in the NSCLC group was higher than that in the benign group and the control group(P<0.05).There was no statistically significant difference between the benign group and the control group(P>0.05).There was no statistically significant difference in the positive rate of CTC among patients with different pathological types of NSCLC(P>0.05).There was a statistical difference in the positive rate of CTC in patients with NSCLC at different TNM stages(P<0.05).The order of the positive rate of CTC from high to low was as follows:stageⅢa,stageⅡ,stage I.The follow-up median disease-free survival(DFS)of patients with CTC-negative NSCLC was longer than that of the positive group.The recurrence and metastasis rates were lower than those in the positive group(P<0.05).The median DFS of NSCLC patients with smoking history,CTC positive patients,high TNM stage and lymph node metastasis was lower than that of NSCLC patients with no smoking history,CTC negative patients,low TNM stage and non-lymph node metastasis(P<0.05).Cox regression analysis showed that TNM stage,CTC and lymph node metastasis were all related factors that affected median DFS of patients wit

关 键 词：非小细胞肺癌 外周血循环肿瘤细胞 TNM分期 预后 

分 类 号：R734.2[医药卫生—肿瘤]