赛肤润联合维生素B_(6)治疗奥西替尼所致手足综合征的临床效果  

Clinical effect of Saifurun combined with vitamin B_(6) in the treatment of patients with hand-foot syndrome caused by Osimertinib

作　　者：郭连英[1] 李九强 王菊美[1] GUO Lianying;LI Jiuqiang;WANG Jumei(Department of Oncology,Handan Central Hospital,Hebei Province,Handan056001,China;Department of Pain,the Third Hospital of Handan,Hebei Province,Handan056001,China)

机构地区：[1]河北省邯郸市中心医院肿瘤内科,河北邯郸056001 [2]河北省邯郸市第三医院疼痛科,河北邯郸056001

出　　处：《中国医药导报》2021年第27期110-112,124,共4页China Medical Herald

基　　金：河北省医学科学研究课题计划项目(20191859)。

摘　　要：目的探讨赛肤润与维生素B6治疗奥西替尼引起的手足综合征(HFS)的临床效果。方法选取河北省邯郸市中心医院2017年1月至2019年6月收治的因口服奥西替尼发生HFS的患者114例,将其按照随机数字表法分为对照组和观察组,每组各57例。对照组口服维生素B6,100 mg/次,3次/d,观察组在对照组的基础上联用赛肤润涂抹手足,2~3滴/次,4次/d。治疗期间两组仍口服甲磺酸奥西替尼,80 mg/次,1次/d。治疗6个月后,观察两组HFS分级情况及生活质量改善率,比较两组治疗前后症状量化评分变化。结果治疗6个月后,观察组HFS分级优于对照组,差异有统计学意义(P<0.05)。治疗6个月后,两组红斑水肿及干燥脱皮的症状量化评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组生活质量改善率高于对照组,差异有统计学意义(P<0.05)。结论赛肤润联合维生素B6可改善由奥西替尼引起的HFS的症状,提高患者的生活质量。Objective To explore the clinical effect of Saifurun combined with vitamin B6 in the treatment of patients with hand-foot syndrome(HFS)caused by Osimertinib.Methods A total of 114 patients with HFS due to oral Osimertinib admitted to Handan Central Hospital of Hebei Province from January 2017 to June 2019 were selected and divided into control group and observation group according to random number table method,with 57 patients in each group.The control group was given vitamin B6 orally,100 mg/time,three times per day.Based on the control group,the observation group was applied with Saifurun on hands and feet,two to three drops per time,four times per day.During the treatment period,both groups still received oral Osimertinib Mesylate,80 mg/time,once a day.After six months of treatment,the HFS grading and the improvement rate of quality of life were observed in the two groups,and the quantitative symptom score changes before and after treatment were compared between the two groups.Results After six months of treatment,the HFS grading of the observation group was better than that of the control group,and the difference was statistically significant(P<0.05).After six months of treatment,the quantitative symptom scores of erythema edema and desiccated skin in both groups were lower than before treatment,and the observation group was lower than the control group,with statistical significance(P<0.05).The improvement rate of quality of life in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Saifurun combined with vitamin B6,it can improve the symptoms of HFS caused by Osimertinib and improve the quality of life of patients.

关 键 词：赛肤润 奥西替尼 手足综合征 

分 类 号：R730.5[医药卫生—肿瘤]