胍丁胺与糖脂代谢  

Agmatine and glycolipid metabolism

作　　者：张燕培 元淑巧[2] 车团结 何津春[1,2] ZHANG Yanpei;YUAN Shuqiao;CHE Tuanjie;HE Jinchun(First School of Clinical Medicine,Lanzhou University,Lanzhou 730000;Clinical Laboratory,First Hospital of Lanzhou University,Lanzhou 730000;Gansu Key Laboratory of Functional Genomics and Molecular Diagnostics,Lanzhou 730000,China)

机构地区：[1]兰州大学第一临床医学院,兰州730000 [2]兰州大学第一医院检验科,兰州730000 [3]甘肃省功能基因组与分子诊断重点实验室,兰州730000

出　　处：《中南大学学报（医学版）》2021年第8期889-893,共5页Journal of Central South University ：Medical Science

基　　金：甘肃省自然科学基金(1308RJZA218);甘肃省中医药管理局科研课题(GZK-2017-50);甘肃省戒毒管理局横向委托课题(2014-02);甘肃省功能基因组与分子诊断重点实验室开放课题(2016-001)。

摘　　要：糖脂代谢异常及其所诱发的各种疾病的患病率逐年上升,已成为当今威胁人类健康的常见问题。寻找更为有效的预防和治疗与糖脂代谢异常相关疾病的方法已成为一个亟待解决的问题。胍丁胺(agmatine)是一种广泛存在于哺乳动物体内的多胺类物质,是L-精氨酸在精氨酸脱羧酶作用下脱羧基后的代谢产物,因此也被称为脱羧精氨酸。目前已发现其具有多种生物学作用。既往研究认为胍丁胺在糖尿病鼠中具有抗糖尿病的作用,不但可以缓解胰岛素抵抗,而且可以刺激胰岛β细胞分泌胰岛素,从而降低血糖。胍丁胺也可通过调节脂质代谢和脂肪酸的氧化等在脂代谢异常及其相关疾病中发挥积极作用。The prevalence of abnormal glucose and lipid metabolism and its relevant diseases has increased year by year,and it has become a problem that threatens human health.Therefore,finding a more effective way to prevent and treat diseases related to abnormal glucose and lipid metabolism has become an urgent public problem.Agmatine is a polyamine substance which widely presents in mammals.It is a metabolite produced by decarboxylation of L-arginine under the action of arginine decarboxylase,hence also known as decarboxylated arginine.Its biological effects have been confirmed.Previous studies have shown that agmatine possesses anti-diabetic effects in diabetic animals.Agmatine not only increases the insulin secretion formβ-pancreatic cells to inhibit the hyperglycemia,but also attenuates insulin resistance in rats.Agmatine also plays a positive role in lipid metabolism disorders and related diseases by modulating lipid metabolism and fatty acid oxidation.

关 键 词：胍丁胺 糖尿病 高脂血症 

分 类 号：R363[医药卫生—病理学]