SMILE术暗适应下瞳孔直径的影响因素分析  

Clinical Study on Pupil Diameter Under Dark Adaptation of SMILE

作　　者：林海芹 刘泉[1] LIN Hai-qin;LIU Quan(State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-sen University,Guangzhou 510060,China)

机构地区：[1]中山大学中山眼科中心眼科学国家重点实验室,广东广州510060

出　　处：《中山大学学报（医学科学版）》2021年第5期756-761,共6页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：国家自然科学基金(31671000)。

摘　　要：【目的】比较手持瞳孔测量仪与Sirius眼前节分析系统对暗适应下瞳孔直径测量的一致性,探究SMILE术后暗适应下瞳孔直径的变化以及影响暗适应下瞳孔直径的因素。【方法】本研究分为两部分:①纳入接受SMILE手术的患者128人(共256只眼),采用两种方法对同一只眼术前和术后3月的暗适应下瞳孔直径进行测量,数据采用配对资料的符号秩和检验和简单线性回归分析;②回顾性研究,纳入行SMILE手术患者2237人(共4179只眼),采集其暗适应下瞳孔直径、年龄、性别、眼别、主视眼及等效球镜度等数据进行分析。【结果】用手持瞳孔测量仪测量(x)和用Sirius眼前节分析系统测量暗适应下瞳孔直径(y)的差异无统计学意义(P=0.369),行简单线性回归分析:=0.929x+0.453,r^(2)=0.858。SMILE术前(x,6.80±0.88)mm较术后3月的暗适应下瞳孔直径(y,6.65±0.73)mm大,且其差异有统计学意义(P=0.018),行简单线性回归分析:ŷ1.050x-0.223,r^(2)=0.771。暗适应下瞳孔直径影响因素的流行病学研究:①对暗适应下瞳孔直径与年龄行相关性分析,发现两者呈负相关(r=-0.204,P=0.000)。②男组暗适应下瞳孔直径(6.35±0.75)mm较女组(6.27±0.74)mm大,且其差异有统计学意义(P=0.000)。③右眼组(6.29±0.74)mm及左眼组(6.31±0.75)mm差异无统计学意义。④主视眼组(6.30±0.73)mm及非主视眼组(6.31±0.75)mm差异无统计学意义。⑤低度(6.23±0.73)mm、中度(6.31±0.74)mm、高度(6.30±0.75)mm和超高度近视组(6.33±0.70)mm间的差异无统计学意义。【结论】①手持瞳孔测量仪及Sirius眼前节分析系统对术前暗适应下瞳孔直径的测量具有一致性,在屈光手术中可使用手持瞳孔测量仪替代SIRIUS眼前节分析系统对暗适应下瞳孔直径进行测量。②SMILE术后3月患者暗适应下瞳孔直径有变小趋势。③术前暗适应下瞳孔直径与年龄呈负相关,男性的术前暗适应下瞳孔直径较女性大,术�【Objective】To compare the consistency between handheld pupil measuring instrument and Sirius anterior segment analysis system in measuring pupil diameter under dark adaptation,and explore the changes of pupil diameter under dark adaptation after small incision lenticule extraction(SMILE)surgery and the factors affecting pupil diameter under dark adaptation.【Methods】This study is divided into two parts.①One hundred and twenty-eight patients(256 eyes)who underwent SMILE surgery were included in this study.Besides,the pupil diameter under dark adaptation of the same eye,before and 3 months after surgery,were measured by two methods.The data were analyzed by Wilcoxon matched-pairs signed rank sum test and simple linear regression analysis.②A retrospective study included 2237 patients(4179 eyes in total)who underwent SMILE surgery,and data of pupil diameter under dark adaptation,age,gender,eye type,dominant eye and equivalent spherical power were collected for analysis.【Results】There was no significant difference between the pupil diameter under dark adaptation measured by hand-held pupil measuring instrument(y)and that measured by Sirius anterior segment analysis system(P=0.369).Simple linear regression analysis was performed(y=0.929 x+0.453,r^(2)=0.858).The difference of pupil diameter under dark adaptation before SMILE surgery(x,6.80±0.88)mm and pupil diameter under dark adaptation 3 months after SMILE surgery(y,6.65±0.73)mm was statistically significant(P=0.018).Simple linear regression analysis showed that y=1.050 x-0.223 and r^(2)=0.771.This is an epidemiological study on influencing factors of pupil diameter under dark adaptation.①Correlation analysis between pupil diameter under dark adaptation and age showed that there was a negative correlation between them(r=-0.204,P=0.000).②The pupil diameter under dark adaptation of male group(6.35±0.75)mm was significantly different from that of female group(6.27±0.74)mm(P=0.000).③There was no significant difference between the right eye group(6

关 键 词：暗适应下瞳孔直径 瞳孔相关因素 眼别 主视眼 术前等效球镜度 

分 类 号：R779.6[医药卫生—眼科]