维生素D与恶性肿瘤发病的关系  

Relationship between vitamin D and malignancy

作　　者：吴哲哲 柴小艳 孙丽娟[2] Wu Zhezhe;Chai Xiaoyan;Sun Lijuan(Digestive Surgery,Xijing Hospital,Xi′an 710032,Shaanxi,China;Department of Life Science and Medicine,Northwest University,Xi′an 710069,Shaanxi,China)

机构地区：[1]西京医院消化外科,西安710032 [2]西北大学生命科学与医学部,西安710069

出　　处：《肿瘤代谢与营养电子杂志》2021年第4期450-454,共5页Electronic Journal of Metabolism and Nutrition of Cancer

摘　　要：维生素D为脂溶性维生素,具有刺激肠道钙和磷酸盐的吸收,肾钙和磷酸盐的再吸收和调节骨矿物质的代谢作用。维生素D缺乏易引起佝偻病、骨软化症、骨质疏松症及手足抽搐症;过量摄入维生素D可引起维生素D中毒。维生素D主要来源于皮肤合成和食物。经常晒太阳是获得充足有效的维生素D的最好来源。维生素D与多种恶性肿瘤的发生、发展有关,主要集中在两点:①观察不同人群机体维生素D水平与恶性肿瘤发病的关系;②补充维生素D对改变恶性肿瘤的发生率的影响。本文就维生素D和多种恶性肿瘤如结直肠癌、皮肤癌等之间的相关研究展开综述发现,目前缺乏充分的证据支持,机体较高维生素D水平,可降低恶性肿瘤的发病风险。由于目前关于维生素D与肿瘤发生、发展研究较少,并且研究结果容易受到气候、地理环境、饮食等因素的影响,需要进一步大样本的前瞻性研究,明确维生素D与肿瘤的关系。Vitamin D is fat-soluble vitamin,which can stimulate the absorption of intestinal calcium and phosphate,absorb renal calcium and phosphate,and regulate the metabolism of bone minerals.Vitamin D deficiency easily leads to rickets,steomalacia,osteoporosis,and hand and foot spasm;excessive intake of vitamin D can cause vitamin D poisoning.It mainly comes from skin synthesis and food.Frequent sun exposure is the best source for obtaining adequate and effective vitamin D.Adults are often exposed to sunlight,generally do not develop vitamin D deficiency disease.In recent years,it has shown that vitamin D is related to the development of multiple malignant tumors.It is mainly focused on two points,one is to observe the relationship between vitamin D levels in different groups and malignant tumors,and the other is whether artificial vitamin D supplementation will change the incidence of malignant tumors.This paper reviews the relevant studies between vitamin D and various malignant tumors such as colorectal cancer and skin cancer,and the results found that there is a lack of sufficient evidence to support the body′s higher vitamin D levels,which can reduce the risk of malignant tumors.Since there are few studies on vitamin D and tumor development and development,and the results are vulnerable to climate,geographical environment,dietary factors,further prospective studies of large samples may be needed to further clarify the relationship between vitamin D and tumor.

关 键 词：维生素D 恶性肿瘤 结肠癌 皮肤癌 

分 类 号：R730.2[医药卫生—肿瘤]