A cross-sectional study on traditional Chinese medicine syndromes distribution for chronic atrophic gastritis based on data mining  

作　　者：Ze-Hui Chen Li-Xin Ma Yue Wei Hai-Xiao Han En-Long Xing Jin-Xiang Yang 

机构地区：[1]Institute of Information on Traditional Chinese Medicine,Chinese Academy of Chinese Medical Sciences 100700,China [2]Key Laboratory of Public Health Safety of Hebei Province,College of Public Health,Hebei University,Hebei 071002,China [3]The Third Affiliated Hospital of Beijing University of Chinese Medicine,Beijing 100029,China [4]Dongfang Hospital of Beijing University of Chinese Medicine,Beijing 100078,China [5]Beijing Rehabilitation Hospital of Capital Medical University,Beijing 100144,China

出　　处：《Medical Data Mining》2021年第3期10-23,共14页TMR医学数据挖掘

基　　金：This study was supported by the National Natural Science Foundation of China(No.81173232).

摘　　要：Background:Chronic atrophic gastritis(CAG)is a common digestive system disease characterized by reduced gastric mucosa inherent glands and often accompanied by intestinal metaplasia and dysplasia.Traditional Chinese medicine believes that syndrome elements dampness and blood stasis are closely related to the occurrence and development of CAG and promote the occurrence of precancerous lesions of gastric cancer.However,there is a lacking of more in-depth and detailed study on the above syndrome elements.This study aimed to made a quantitative description by cross-sectional study on the frequency of key syndrome elements dampness and blood stasis of CAG.Methods:201 CAG patients who met with inclusion criteria were divided into 4 groups including:only dampness group,only blood stasis group,none of dampness and blood stasis group,dampness and blood stasis group according to their four diagnostic information.The severities and levels of patients’clinical symptoms,pathological signs and patient-reported outcome scale used as evaluation indexes were collected.Data mining method of exploratory factor analysis was used for statistics.Results:The results suggested that the frequencies of dampness and blood stasis were reflected in the severity and levels of gastric symptoms,helicobacter pylori infection and the distribution and severity of dysplasia.And blood stasis played a more prominent role in promoting the progression of the CAG to cancer.Conclusion:Our results might provide a quantitative syndrome description for the traditional Chinese medicine differentiation in treating precancerous lesions of gastric cancer and preventing gastric cancer.

关 键 词：Chronic atrophic gastritis Precancerous lesions of gastric cancer Traditional Chinese medicine syndrome Data mining 

分 类 号：R57[医药卫生—消化系统]