An Evolved Human-specific Epigenetic Mechanism for Cortical Expansion and Gyrification  

作　　者：Dan Li Yunli Xie 

机构地区：[1]Department of Anesthesia,The State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science,Institutes of Brain Science,and Zhongshan Hospital,Fudan University,Shanghai 200032,China

出　　处：《Neuroscience Bulletin》2021年第9期1370-1372,共3页神经科学通报（英文版）

基　　金：This Research Highlight was supported by the National Key Research and Development Program of China(2018YFA0108000);the National Natural Science Foundation of China(31872763);Shanghai Municipal Science and Technology Major Project(2018SHZDZX01,19JC1411003)and ZJLab.

摘　　要：Over evolution,the human species has acquired higher cognitive function,which helps to distinguish Homo sapiens from other mammals.Particularly,humans have a large neocortex through the evolutionary expansion of the brain,which is believed to be instrumental in the establishment of comprehensive neuronal circuits[1,2].A hallmark of the human brain is the highly convoluted brain surface structure,named gyrification or cortical folding,consisting of gyri and sulci,which significantly increase the cortical surface area.However,the mechanisms underlying the cortical expansion remain elusive.

关 键 词：CORTEX EXPANSION FOLDING 

分 类 号：R741[医药卫生—神经病学与精神病学]