自拟出血性中风1、2号方治疗急性出血性中风疗效评价  

Effects of self-designed hemorrhagic stroke prescriptions No.1 and No.2 on C-reactive protein and tumor necrosis factor in patients with acute hemorrhagic stroke

作　　者：张超 潘平康 吴宗涛 杨甲平 王晓虎 唐勇 陈亮 王晓玲 ZHANG Chao;PAN Ping-kang;WU Zong-tao;YANG Jia-ping;WANG Xiao-hu;TANG Yong;CHEN Liang;WANG Xiao-ling(Department of Encephalology,Ankang Traditional Chinese Medicine Hospital,Ankang 725000,Shaanxi,CHINA)

机构地区：[1]安康市中医医院脑病科,陕西安康725000

出　　处：《海南医学》2021年第19期2503-2506,共4页Hainan Medical Journal

基　　金：陕西省中医药管理局立项课题(编号:LCPT045)。

摘　　要：目的探究自拟出血性中风1、2号方治疗急性出血性中风的效果及其对患者C反应蛋白(CRP)及肿瘤坏死因子(TNF)水平的影响。方法回顾性分析2018年1月至2019年6月于安康市中医医院治疗的161例急性出血性中风患者的临床资料,按治疗方式不同将其分为观察组81例和对照组80例,对照组患者接受常规西药治疗,观察组患者在对照组治疗的基础上加用自拟出血性中风1、2号方治疗,分别在入组时、发病第7天、第21天测定并比较两组患者的血肿体积、水肿带面积、炎症因子、格拉斯哥昏迷(GCS)评分及神经功能缺损(NIHSS)评分,并比较两组患者的不良反应发生情况。结果治疗前两组患者的血肿体积和水肿带面积比较差异均无统计学意义(P>0.05);治疗后第7天和第21天时,观察组患者的水肿带面积明显低于对照组,差异有统计学意义(P<0.05),但两组患者的血肿体积比较差异无统计学意义(P>0.05);治疗前两组患者的CRP及TNF水平比较差异均无统计学意义(P>0.05);治疗第21天时观察组患者的TNF水平明显低于对照组,而治疗第7天和第21天时,观察组患者的CRP水平明显低于对照组,差异均有统计学意义(P<0.05);治疗前及治疗第7天时,两组患者的NIHSS及GCS评分比较差异均无统计学意义(P>0.05),治疗第21天时,观察组患者的GCS评分明显高于对照组,NIHSS评分明显低于对照组,差异均有统计学意义(P<0.05);两组治疗期间各类不良反应总发生率比较差异无统计学意义(P>0.05)。结论口服出血性中风1、2号方联合西医治疗急性出血性中风有利于促进患者周围水肿带吸收,降低炎症反应,减轻神经功能缺损,临床治疗效果确切。Objective To explore the effect of self-designed hemorrhagic stroke prescriptions No.1 and No.2 in the treatment of acute hemorrhagic stroke and their effects on C-reactive protein(CRP) and tumor necrosis factor(TNF)levels of patients. Methods The clinical data of 161 patients with acute hemorrhagic stroke treated in Ankang Traditional Chinese Medicine Hospital from January 2018 to June 2019 were retrospectively analyzed. They were divided into an observation group(n=81) and a control group(n=80) according to different treatment methods. The control group received conventional western medicine treatment, and the observation group was treated with self-designed hemorrhagic stroke prescriptions No.1 and No. 2 on the basis of control group. Hematoma volume, edema zone area, inflammatory factors, Glasgow coma(GCS) score, and neurological impairment(NIHSS) score were measured and compared between the two groups at the time of enrollment, on day 7 and 21 of onset, respectively. The incidences of adverse reactions were compared between the two groups. Results There was no significant difference in hematoma volume and edema zone area between the two groups before treatment(P>0.05);On day 7 and 21 after treatment, the area of edema zone in the observation group was significantly lower than that in the control group, and the difference was statistically significant(P<0.05). However, there was no statistically significant difference in hematoma volume between the two groups(P>0.05). There was no significant difference in CRP and TNF levels between the two groups before treatment(P>0.05).The TNF level in the observation group was significantly lower than that in the control group on day 21, and the CRP level in the observation group was significantly lower than that in the control group on day 7 and 21, with statistically significant difference(P<0.05). Before treatment and on day 7 after treatment, there was no significant difference in NIHSS and GCS scores between the two groups(P>0.05). On day 21 of treatment, the GCS sco

关 键 词：出血性中风 出血性中风1、2号方 C反应蛋白 肿瘤坏死因子 疗效 

分 类 号：R743.3[医药卫生—神经病学与精神病学]