血清标志物ProGRP、Spondin-2、PSA联合SPECT检查对前列腺癌骨转移的诊断价值  

Diagnostic value of serum marker ProGRP,Spondin-2 and PSA plus SPECT in the diagnosis of bone metastasis of prostate cancer

作　　者：王莹莹 陶绍能 刘小岑 陈晓磊 杨继文 葛俊亮 WANG Yingying;TAO Shaoneng;LIU Xiaocen;CHEN Xiaolei;YANG Jiwen;Ge Junliang(Department of Nuclear Medicine,The First Affiliated Hospital of Wannan Medical College,Wuhu 241001,China)

机构地区：[1]皖南医学院第一附属医院弋矶山医院核医学科,安徽芜湖241001

出　　处：《皖南医学院学报》2021年第5期448-450,454,共4页Journal of Wannan Medical College

基　　金：皖南医学院中青年科研基金项目(WK2018F29)。

摘　　要：目的:探讨血清标志物胃泌素释放肽前体(ProGRP)、脊柱蛋白-2(Spondin-2)、前列腺特异性抗原(PSA)联合单光子发射型计算机断层成像(SPECT)检查对前列腺癌(PCa)骨转移的诊断价值。方法:收集2018年7月~2020年7月弋矶山医院确诊的62例PCa患者,骨转移组40例,无骨转移组22例;检测血清标志物ProGRP、Spondin-2、PSA。比较两组患者ProGRP、Spondin-2、PSA差异,分析其与PCa骨转移的相关性。结果:与无骨转移组比较,骨转移组患者Spondin-2、ProGRP、PSA升高(P<0.05);>2个骨转移灶患者与≤2个骨转移灶患者相比,血清Spondin-2增高(P<0.05),而两组骨转移患者PSA及ProGRP比值差异无统计学意义(P>0.05)。3组患者fPSA/PSA比值差异无统计学意义(P>0.05)。Logistic回归分析显示,血清标志物PSA(OR=1.149)、Spondin-2(OR=1.438)、ProGRP(OR=1.211)水平升高是PCa骨转移的危险因素(P<0.05)。结论:血清标志物ProGRP、Spondin-2、PSA与PCa骨转移相关,为其危险因素;fPSA/PSA与骨转移无关。Objective:To investigate the diagnostic value of combined serum maker ProGRP,Spondin-2 and PSA with single-photon emission computed tomography(SPECT)in the diagnosis of bone metastasis in patients of prostate cancer(PCa).Methods:Sixty-two patients with PCa diagnosed in our hospital were included from July 2018 to July 2020.Of the 62 patients,40 were bone metastasis,and 22 were free.All patients underwent measurement of serum maker ProGRP,Spondin-2 and PSA.The difference of ProGRP,Spondin-2 and PSA was compared between the two groups for analysis of correlation of PCa with bone metastasis.Results:Compared with the non-bone metastasis group,the values of Spondin-2,ProGRP and PSA were significantly increased in the two groups of patients with bone metastasis(P<0.05),and the serum Spondin-2 value was significantly higher in patients with>2 bone metastases than those with≤2 bone metastases(P<0.05).However,there was no significant difference in the ratio of PSA and ProGRP between the two groups of patients with bone metastases(P>0.05),and in the ratio of fPSA/PSA among the three groups of patients(P>0.05).Logistic regression analysis showed that elevated levels of serum marker PSA(OR=1.149),Spondin-2(OR=1.438)and ProGRP(OR=1.211)were risk factors for bone metastasis of prostate cancer(P<0.05).Conclusion:The serum marker ProGRP,Spondin-2 and PSA are risk factors for,and strongly related to bone metastasis in patients of prostate cancer,yet fPSA/PSA has no relation with bone metastasis in such victims.

关 键 词：前列腺癌骨转移 单光子发射型计算机断层成像 前列腺特异性抗原 脊柱蛋白-2 胃泌素释放肽前体 

分 类 号：R737.25[医药卫生—肿瘤] R446.11[医药卫生—临床医学]