局部晚期下咽癌根治性放射治疗的疗效及预后因素分析  

Study on the clinical efficacy of radical radiotherapy in locally advanced hypopharyngeal carcinoma and prognostic factors

作　　者：汪庚明[1] 周燕[1] 孙谦[1] 周育夫[1] 丁建明 周士祥 郭术楠 陈蔓 WANG Geng-ming;ZHOU Yan;SUN Qian;ZHOU Yu-fu;DING Jian-ming;ZHOU Shi-xiang;GUO Shu-nan;CHEN Man(Department of Radiation Oncology,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui 233004,China)

机构地区：[1]蚌埠医学院第一附属医院肿瘤放疗科,安徽蚌埠233004

出　　处：《蚌埠医学院学报》2021年第9期1158-1160,共3页Journal of Bengbu Medical College

基　　金：安徽省临床医学优先发展重点专科基金(卫科教秘[2018]291号)。

摘　　要：目的:分析根治性放射治疗对局部晚期下咽癌的临床疗效,并对其影响预后的相关因素进行评价。方法:回顾性分析2016年10月至2018年12月25例局部晚期下咽癌病人的临床资料,通过Kaplan-Meier法计算总生存时间,应用Cox比例风险回归模型进行单因素和多因素分析。结果:近期有效率为100%。中位生存时间为17个月,2年生存率为32.0%。通过单因素分析,结果显示N分期、临床分期、近期疗效、是否同步化疗与生存预后有关(P<0.01)。多因素分析结果表明,临床分期和是否同步化疗是下咽癌病人预后的独立影响因素(P<0.01和P<0.05)。结论:根治性放射治疗局部晚期下咽癌近期疗效确切,临床分期和是否同步化疗是影响其预后的独立危险因素。Objective:To analyze the clinical effects of radical radiotherapy in the treatment of locally advanced hypopharyngeal cancer, and evaluate the prognostic factors.Methods:The clinical data of 25 patients with locally advanced hypopharyngeal carcinoma from October 2016 to December 2018 were retrospectively analyzed.The overall survival of patients was calculated using Kaplan-Meier method.The Cox model was used for univariate analysis and multivariate analysis.Results:The recent effective rate was 100%.The median surviual time was 25 months.The 2-year surviual rate was 32.0%.The results of univariate analysis indicated that the N stage, clinical stage, recent effective rate and concurrent chemotherapy were the prognostic factors(P<0.01).The results of multivariate analysis showed that the clinical stage and concurrent chemotherapy were the independent prognostic factors(P<0.01和P<0.05).Conclusions:The short-term effects of radical radiotherapy for locally advanced hypopharyngeal carcinoma is definite.The clinical stage and concurrent chemotherapy are the independent prognostic factors.

关 键 词：咽喉肿瘤 预后 放射治疗 

分 类 号：R739.63[医药卫生—肿瘤]