菠萝蜜低聚肽对db/db糖尿病小鼠血糖的影响  

The hypoglycemic effects of jackfruit oligopeptides in db/db diabetic mice

作　　者：刘欣然[1] 康家伟 王天星 郝云涛 珠娜 刘睿[1] 胡佳妮 毛瑞雪[1] 李勇[1] LIU Xinran;KANG Jiawei;WANG Tianxing;HAO Yuntao;ZHU Na;LIU Rui;HU Jiani;MAO Ruixue;LI Yong(Department of Nutrition and Food Hygiene,School of Public Health,Peking University,Beijing 100191,China)

机构地区：[1]北京大学公共卫生学院营养与食品卫生学系,北京100191

出　　处：《科技导报》2021年第18期94-100,共7页Science & Technology Review

摘　　要：关于菠萝蜜的研究显示其具有一定的降血糖作用,但尚未有关于菠萝蜜低聚肽(Jackfruit oligopeptides,JOPs)降血糖的研究。通过菠萝蜜低聚肽干预,研究其对db/db糖尿病模型小鼠血糖的影响作用。将db/db糖尿病小鼠模型,随机分为3个菠萝蜜低聚肽组(0.2 g/kg·bw、0.4 g/kg·bw、0.8 g/kg·bw)以及糖尿病模型对照组、二甲双胍对照组、乳清蛋白对照组;并选用db/m小鼠作为非糖尿病小鼠空白对照。经过为期6周的干预,检测小鼠空腹血糖、糖耐量实验血糖曲线下面积及组织中糖原含量。结果表明,菠萝蜜低聚肽可显著降低db/db糖尿病小鼠空腹血糖水平,显著降低糖耐量实验血糖曲线下面积(P<0.05),其效果以0.4 g/kg·bw剂量组最为显著。菠萝蜜低聚肽干预可有效降低糖尿病小鼠的血糖水平,改善糖耐量,具有辅助降血糖作用。To study the hypoglycemic effects of jackfruit oligopeptides in db/db diabetic mice,48 db/db diabetic mice are randomly divided into six groups(with 8 mice in each group):three jackfruit oligopeptides groups(with 0.2 g/kg·bw,0.4 g/kg·bw and 0.8 g/kg·bw JOPs,respectively,by intragastric administration),a diabetic model group,a metformin control group(with 0.2 g/kg·bw metformin hydrochloride enteric-coated tablets aqueous solution by intragastric administration)and a whey protein control group(with 0.4 g/kg·bw whey protein aqueous solution by intragastric administration),while 10 db/m mice are used as the blank control for non-diabetic mice.The fasting glucose,the OGTT-AUC,the liver glycogen and the muscle glycogen are measured during the intervention.It is shown that the JOPs could decrease the fasting blood glucose and the OGTT-AUC in the diabetic mice(P<0.05),especially in the 0.4g/kg·bw-dose group.The long-term jackfruit oligopeptides intervention can effectively reduce the blood glucose level and improve the glucose tolerance of diabetic mice.

关 键 词：菠萝蜜低聚肽 降血糖 糖耐量 DB/DB糖尿病小鼠 

分 类 号：R587.1[医药卫生—内分泌]