机构地区:[1]河北省青县人民医院放疗科,062600 [2]河北省沧州市人民医院精准放疗中心
出 处:《河北医药》2021年第19期2944-2947,共4页Hebei Medical Journal
摘 要:目的研究放射性碘125粒子植入治疗肺癌并咯血的止血效果。方法回顾性分析2014年9月至2018年2月收治的肺癌伴咯血患者42例,根据其治疗方式不同,分成放射性碘125粒子植入治疗组22例(研究组)和内科治疗组20例(对照组)。分别观察2组近期及远期止血治疗效果和肿瘤的局部控制率。结果近期止血效果:研究组治愈17例(77.3%),有效3例(13.6%),无效2例(9.1%);对照组20例中治愈2例(10%),有效4例(20%),无效14例(70%)。研究组近期止血有效率明显高于对照组(P<0.01)。远期止血效果:研究组治愈18例(81.8%),有效2例(9.1%),无效2例(9.1%);对照组20例中治愈1例(5%)例,有效2例(10%),无效17例(85%)。研究组的远期止血有效率明显高于对照组(P<0.01)。肿瘤局部效果:研究组患者中完全缓解12例(54.5%),部分缓解9例(40.9%),肿瘤局部治疗有效率达95.5%,而对照组肿瘤有效率为0。研究组治疗有效率显著高于对照组(P<0.01)。治疗后,2组第1秒用力呼气容积(FEV1)、用力肺活量(FVC)和1秒用力呼气量占用力肺活量比值(FEV1/FVC)均明显升高,且研究组升高更明显,组间差异有统计学意义(P<0.05)。患者均无严重不良反应发生。结论放射性碘125粒子植入治疗可以有效治疗肺癌伴咯血患者,是一种安全有效的治疗手段。Objective To investigate the hemostatic effects of radioactive iodine 125 seed implantation through CT-guided percutaneous puncture in treatment of lung cancer complicated by hemoptysis.Methods The clinical data about 42 patients with lung cancer complicated by hemoptysis who were treated in our hospital from September 2014 to February 2018 were retrospectively analyzed.According to the different treatment methods,these patients were divided into research group(n=22,radioactive iodine 125 seeds implantation treatment)and control group(n=20,internal medicine treatment).The short-term and long-term hemostatic effects as well as the local control rate of tumor were observed and compared between the two groups.Results In the short-term hemostasis effects:17 cases(77.3%)were cured,3 cases(13.6%)were effective,2 cases(9.1%)were ineffective in research group,and 2 cases(10%)were cured,4 cases(20%)were effective and 14 cases(70%)were ineffective in control group.The short-term hemostasis effective rate in research group was significantly higher than that in control group(P<0.01).In the long term hemostasis effects:18 cases(81.8%)were cured,2 cases(9.1%)were effective and 2 cases(9.1%)were ineffective in research group,and 1 case(5%)were cured,2 cases(10%)were effective and 17 cases(85%)were ineffective in control group.The long-term hemostatic effective rate in research group was significantly higher than that in control group(P<0.01).Moreover in the local effects:12 cases(54.5%)had complete remission and 9 cases(40.9%)had partial remission in research group,and the effective rate of tumor local treatment was 95.5%,however,which in control group was 0.The effective rate in research group was significantly higher than that in control group(P<0.01).No serious adverse reactions were found in both groups.Conclusion The radioactive iodine 125 seed implantation therapy can effectively treat lung cancer complicated by hemoptysis,which is a safe and effective treatment way.
关 键 词:肺癌 咯血 放射性碘125粒子植入 疗效
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