机构地区:[1]河北省秦皇岛市海港医院神经内科,066000
出 处:《河北医药》2021年第19期2965-2968,共4页Hebei Medical Journal
摘 要:目的分析丁苯酞注射液联合银杏二萜内酯注射液治疗急性脑梗死的临床疗效及对侧支循环的改善作用。方法126例研究对象为2018年5月至2020年1月神经内科收治的急性脑梗死患者,随机分为试验组和对照组,每组63例。对照组给予丁苯酞注射液治疗,试验组给予丁苯酞注射液联合银杏二萜内酯注射液治疗,比较治疗后2组临床疗效及治疗前后神经功能缺损(NIHSS)评分、Barthel指数(BI)评分、血液流变学指标[血浆黏度、全血高切黏度、纤维蛋白原(Fg)]、侧支循环数及侧支循环分级。结果试验组患者经两药联合治疗后总有效率为90.48%,明显高于对照组的76.19%(P<0.05)。治疗后2组患者NIHSS评分较治疗前明显降低、BI评分较治疗前明显升高(P<0.05),且试验组2评分改善明显优于对照组(P<0.05)。治疗后2组患者血浆黏度、全血高切黏度、Fg水平均较治疗前明显降低(P<0.05),试验组明显低于对照组(P<0.05)。治疗后2组患者侧支循环数均较治疗前明显增加(P<0.05),试验组明显多于对照组(P<0.05)。治疗后2组患者侧支循环分级均较治疗前明显改善(P<0.05),试验组改善程度明显高于对照组(P<0.05)。结论丁苯酞注射液联合银杏二萜内酯注射液治疗急性脑梗死临床效果显著,可明显促进神经功能恢复,有效提高侧支循环的数量和分级,在提高患者生活质量方面具有重要意义。Objective To investigate the therapeutic effects of butylphthalide injection combined with ginkgolide injection on acute cerebral infarction and its improvement effects on collateral circulation.Methods A total of 126 patients with acute cerebral infarction who were treated in our hospital from May 2018 to January 2020 were randomly divided into experimental group(n=63)and control group(n=63).The patients in control group were treated by butylphthalide injection,however,the patients in experimental group were treated with butylphthalide injection combined with ginkgolide injection.The NIHSS score,Barthel Index(BI)score,hemorheology indexes[plasma viscosity,whole blood high shear viscosity,fibrinogen(FG)],collateral circulation number and collateral circulation grade were observed and compared betweeen the two groups.Results The total effective rate in experimental group was 90.48%,which was significantly higher than that(76.19%)in control group(P<0.05).After treatment,the NIHSS scores in both groups were significantly decreased,but the BI scores were significantly increased(P<0.05),moreover,the improvement effects in experimental group were more significant than those in control group(P<0.05).After treatment,the plasma viscosity,whole blood high shear viscosity and FG levels in both groups were significantly decreased(P<0.05),moreover,which in experimental group were significantly lower than those in control group(P<0.05).In addition the numbers of collateral circulation in both groups were significantly increased(P<0.05),moreover,which in experimental group were significantly more than those in control group(P<0.05).Furthermore the collateral circulation grades in both groups were significantly improved(P<0.05),and the improvement degree in experimental group was more significant than that in control group(P<0.05).Conclusion The butylphthalide injection combined with ginkgolide injection has significant clinical effects in treatment of acute cerebral infarction,which can significantly promote the recovery of neu
关 键 词:丁苯酞注射液 银杏二萜内酯注射液 急性脑梗死 临床疗效 侧支循环
分 类 号:R743.33[医药卫生—神经病学与精神病学]
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