伽玛刀分次治疗听神经瘤的疗效观察  

The effect of gamma knife in the treatment of acoustic neuroma

作　　者：顾冲[1] 李璐 Gu Chong;Li Lu(Gamma Knife Center,Huaian No.3 Peoples Hospital,Huaian Jiangsu 223001,China)

机构地区：[1]江苏省淮安市第三人民医院伽玛刀中心,淮安223001

出　　处：《立体定向和功能性神经外科杂志》2021年第3期154-157,共4页Chinese Journal of Stereotactic and Functional Neurosurgery

摘　　要：目的观察陀螺旋转式γ刀分次治疗听神经瘤的临床疗效。方法应用上海伽玛星科技公司的GMX B型陀螺旋转式钴60立体定向放射治疗系统(陀螺旋转式γ刀),分次治疗听神经瘤患者28例,男11例,女17例,年龄18~85岁,肿瘤直径1.6 cm~4.3 cm,50%~60%等剂量曲线包绕,单次剂量300 cGy~450 cGy。周边处方剂量3000 cGy~4500 cGy,中心6000 cGy~9350 cGy,1次/日,5次/周,一疗程8~11次。结果随访3~132个月,1、4、7、10年肿瘤控制率分别为100.0%、89.3%、85.7%、82.1%,听力保存率分别为82.1%、57.1%、50.0%、39.3%。面神经和三叉神经功能的保存率分别为96.4%、82.1%、78.6%、75.0%,KPS评分上升分别为92.9%、78.6%、71.4%、57.1%。结论γ刀分次治疗听神经瘤近期疗效满意,神经功能保存率高,是听神经瘤综合治疗的又一种有效手段之一。Objective To observe the clinical effect of gyro rotary gamma knife in the treatment of acoustic neuroma.Methods Twenty eight patients with acoustic neuroma were treated by GMX-B gyrotrotational cobalt 60 stereotactic radiotherapy system(gyrotrotational gamma knife)of Shanghai gamma star technology company.There were 11 males and 17 females,aged 18~85 years old,with tumor diameter of 1.6 cm~4.3 cm,50%~60%isodose curve wrapping,single dose of 300 cgy~450 cgy.The peripheral prescription dose was 3000 cgy~4500 cgy,and the central prescription dose was 6000 cgy~9350 cgy,once a day,5 times a week,8~11 times a course of treatment.Results During the follow-up of 3-132 months,the tumor control rate was 100.0%,89.3%,85.7%,82.1%respectively in 1,4,7,10 years.The hearing preservation rate was82.1%、57.1%、50.0%、39.3%respectively.The preservation rate of facial nerve and trigeminal nerve function was 96.4%,82.1%,78.6%,75.0%respectively.The KPS score increased by 92.9%,78.6%,71.4%,57.1%respectively.Conclusion Gamma knife fractionated treatment of acoustic neuroma has satisfactory short-term effect and high preservation rate of nerve function.It is another effective method for comprehensive treatment of acoustic neuroma.

关 键 词：听神经瘤 立体定向放射治疗系统 分次治疗 放射治疗 

分 类 号：R739.41[医药卫生—肿瘤]