Different physiopsychological changes between AMS-susceptible and AMS-resistant pre-selected Antarctic expeditioners in Tibet  

作　　者：WU Xiaopei LIU Shiying WANG Xi WANG Jianan QIN Pengrui XU Chengli 

机构地区：[1]Institute of Basic Medical Sciences Chinese Academy of Medical Sciences,School of Basic Medicine Peking Union Medical College,Beijing 100005,China [2]Center of Environmental and Health Sciences,Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing 100005,China

出　　处：《Advances in Polar Science》2021年第3期239-247,共9页极地科学进展（英文版）

基　　金：funded by the CAA(Grant no.JDXT2019-03);the National Antarctic Expedition Training Base of China(Medical Monitoring and Screening of the 37th Chinese Antarctic Pre-selected Expeditioners of Kunlun Station During Plateau Adaptive Training in Tibet);the CAA(Formulation of Technical Specifications for Physiological Health Monitoring of Antarctic Expeditioners).

摘　　要：Through dynamically monitoring changes of acute mountain sickness(AMS)occurrences,cardiopulmonary function and mood states from Shanghai(4 m)to Lhasa(3650 m)and Yambajan(4300 m),Tibet,we obtained physiopsychological data of the 37th Chinese Antarctic pre-selected expeditioners for Kunlun Station.Through analyzing different physiopsychological changes between AMS-susceptible(AMS-S)and AMS-resistant(AMS-R)expeditioners,we would explore indicators to screen hypoxia-susceptible expeditioners.According to AMS occurrences evaluated by Lake Louise Score(LLS)in Yambajan,we divided the expeditioners(n=24,31.92±5.76 a)into AMS-S and AMS-R groups.Using a series of medical instrumentsand questionnaires,we monitored their cardiopulmonary function and mood states,and analyzed the differences of physiopsychological parameters between AMS-S and AMS-R groups.Compared with Shanghai,when expeditioners arrived in Yambajan,in both AMS-S and AMS-R groups,oxygen saturation(SpO2)significantly decreased,and blood pressure significantly increased(P<0.05).As for electrocardiogram(ECG),interval from the beginning to the end of QRS complex wave(QRS),interval from the beginning of QRS complex wave to the end of T wave(QT),interval between 2 adjacent P waves(PP)and interval between 2 adjacent R waves(RR)significantly decreased,heart rate(HR)and HR-corrected QT interval(QTc)significantly increased(P<0.05).Cardiac contractility and pumping function significantly decreased,systemic vascular resistance significantly increased(P<0.05).Pulmonary airway patency significantly increased(P<0.05).Compared with AMS-R group,AMS-S group showed significantly lower SpO2 and higher stroke volume variation(SVV)in Shanghai,however,significantly lower maximal expiratory flow at 75%of forced vital capacity(MEF75),higher levels of anxiety,fatigue and confusion in Yambajan(P<0.05).In conclusion,when expeditioners arrived at 4300 m,their cardiopulmonary function and mood states changed significantly.SpO2,SVV,MEF75,anxiety,fatigue and confusion maybe could be used as

关 键 词：ANTARCTIC preselected expeditioner hypoxia TIBET acute mountain SICKNESS cardiovascular FUNCTION pulmonary FUNCTION MOOD 

分 类 号：R594.3[医药卫生—内科学]